Department of Otolaryngology-Head and Neck Surgery, Hacettepe University, Ankara, Turkey.
Head Neck. 2012 Mar;34(3):393-7. doi: 10.1002/hed.21738. Epub 2011 Apr 5.
The aim of this study was to investigate the biology of laryngeal squamous cell carcinoma (SCC) to develop effective novel treatment modalities.
Serum concentrations of interleukin (IL)-10, IL-12, and transforming growth factor-β (TGF-β) were evaluated in 50 patients with laryngeal SCC and 15 controls. Results were compared according to tumor-node-metastasis (TNM) classification criteria.
IL-12 and TGF-β levels were not different between the early- and late-stage patients and controls. Tumor classification or nodal involvement was not associated with IL-12 and TGF-β levels. Patients with laryngeal SCC had significantly more detectable serum IL-10 levels than those of controls, given that IL-10 could be detected in only 1 early-stage and 9 late-stage patients, but not in the control group (p = .003). IL-10 was increasingly detectable with advanced T classification (p = .009) and nodal involvement (p = .008).
Serum IL-12 or TGF-β levels were not affected with disease activity and classification; however, serum IL-10 levels were correlated with both parameters.
本研究旨在探讨喉鳞状细胞癌（SCC）的生物学特性，以期开发有效的新型治疗方法。
评估了 50 例喉 SCC 患者和 15 例对照者的血清白细胞介素（IL）-10、IL-12 和转化生长因子-β（TGF-β）浓度。根据肿瘤-淋巴结-转移（TNM）分类标准进行了结果比较。
IL-12 和 TGF-β 水平在早期和晚期患者与对照组之间无差异。肿瘤分类或淋巴结受累与 IL-12 和 TGF-β 水平无关。与对照组相比，喉 SCC 患者的血清 IL-10 水平可检测性明显更高，因为仅在 1 例早期和 9 例晚期患者中可检测到 IL-10，但在对照组中无法检测到（p=0.003）。随着 T 分类（p=0.009）和淋巴结受累（p=0.008）的进展，IL-10 的可检测性逐渐增加。
血清 IL-12 或 TGF-β 水平不受疾病活动和分类的影响；然而，血清 IL-10 水平与这两个参数均相关。
