通过β-C(sp)-H活化实现（杂）芳基碘化物与酮的多功能烷基化反应。
Versatile Alkylation of (Hetero)Aryl Iodides with Ketones via β-C(sp)-H Activation.
作者信息
Zhu Ru-Yi, Liu Luo-Yan, Park Han Seul, Hong Kai, Wu Yongwei, Senanayake Chris H, Yu Jin-Quan
机构信息
Department of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.
Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc. , Ridgefield, Connecticut 06877, United States.
出版信息
J Am Chem Soc. 2017 Nov 15;139(45):16080-16083. doi: 10.1021/jacs.7b09761. Epub 2017 Nov 3.
Abstract
We report Pd(II)-catalyzed β-C(sp)-H (hetero)arylation of a variety of ketones using a commercially available 2,2-dimethyl aminooxyacetic acid auxiliary. Facile installation and removal of the auxiliary as well as its superior scope for both ketones and (hetero)aryl iodides overcome the significant limitations of the previously reported β-C(sp)-H arylation of ketones. The ready availability of ketones renders this reaction a broadly useful method for alkyl-(hetero)aryl coupling involving both primary and secondary alkyls.
摘要
我们报道了使用市售的2,2-二甲基氨基氧基乙酸助剂，钯（II）催化多种酮的β-C（sp）-H（杂）芳基化反应。该助剂的轻松安装和去除，以及其对酮和（杂）芳基碘化物的优异适用范围，克服了先前报道的酮的β-C（sp）-H芳基化反应的重大局限性。酮的容易获得使该反应成为涉及伯烷基和仲烷基的烷基-（杂）芳基偶联的广泛有用的方法。
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