Bahnassy Ahmed A, Aly Nehal N
Departments of Radiology and Anatomy, College of Medicine, Qassim University, Saudi Arabia.
Int J Health Sci (Qassim). 2008 Jan;2(1):119-24.
Congenital neural malformations are complex anomalies, which stem from an abnormality in the embryological development of the nervous system. The development of the nervous system begins by the formation of the neural tube and its subsequent closure. The failure of closure results in neural tube defects (NTD). Defect in the formation of prosencehalon or rhombencephalon will result in holoprosencephaly or Dandy walker complex respectively. The formation of neuroblasts and their migration to cerebral cortex may be altered by many neuronal migration disorders. Lissencephaly, schizencephaly, and heterotopic gray matter are the most prominent.
The objective of the study is relating congenital neural malformations to their corresponding embryological background, and so helping in better understanding the time and the way of the occurrence of such anomalies.
先天性神经畸形是复杂的异常情况，其源于神经系统胚胎发育异常。神经系统的发育始于神经管的形成及其随后的闭合。闭合失败会导致神经管缺陷（NTD）。前脑或后脑形成缺陷将分别导致前脑无裂畸形或Dandy-Walker综合征。许多神经元迁移障碍可能会改变神经母细胞的形成及其向大脑皮质的迁移。无脑回畸形、脑裂畸形和灰质异位是最突出的情况。
该研究的目的是将先天性神经畸形与其相应的胚胎学背景联系起来，从而有助于更好地理解此类异常情况发生的时间和方式。
