Department of Pediatrics, University of California, San Diego, CA 92093, USA.
Pediatr Nephrol. 2010 Jan;25(1):61-74. doi: 10.1007/s00467-008-1020-x.
The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimulation, memory T cells, T cell migration, and their role in both acute and chronic graft destruction. An in depth understanding of the cellular mechanisms that result in both acute and chronic allograft rejection will provide new strategies and targeted therapeutics capable of inducing long-lasting, allograft-specific tolerance.
免疫学领域新发现的爆炸式增长为促进针对移植器官的免疫反应的机制提供了新的见解。同种异体反应的核心是 T 淋巴细胞。这篇综述总结了目前关于同种异体识别、共刺激、记忆 T 细胞、T 细胞迁移及其在急性和慢性移植物破坏中的作用的文献。深入了解导致急性和慢性同种异体排斥反应的细胞机制将提供新的策略和靶向治疗方法，从而能够诱导持久的、针对移植物的耐受性。
