Washington State Department of Health, Office of Epidemiology, PO Box 47812, Olympia, WA 98504-7812, USA.
Prev Chronic Dis. 2011 May;8(3):A50. Epub 2011 Apr 15.
Increasing evidence supports associations between periodontal disease and various chronic conditions. Possible explanations include chronic inflammatory processes, shared pathogens, and shared risk factors, such as smoking and psychosocial stress. The objective of this study was to assess associations of periodontal disease with metabolic syndrome and number of chronic diseases.
As part of the Washington Adult Health Survey, a household-based cross-sectional study conducted during 2006-2007 among adults aged 25 years or older in Washington State, we collected questionnaire data, blood samples, and anthropometric measures. We used these data to assess associations of periodontal disease with metabolic syndrome and the number of self-reported chronic diseases, controlling for age, sex, annual household income, smoking, and psychosocial stress. We used both complete case and multiple imputation Poisson regression analyses.
In the adjusted complete case analysis, 1.4 times as many chronic conditions were found among people with severe compared with no periodontal disease, and people with severe periodontal disease were 1.5 times more likely to have metabolic syndrome than people with no periodontal disease. Arthritis and liver disease were individually associated with severe periodontal disease. Results of the multiple imputation analyses were similar.
These results suggest that people with severe periodontal disease are likely to have more chronic diseases and are more likely to have metabolic syndrome compared with people without periodontal disease. Research about the effectiveness of periodontal treatment to help prevent or control chronic diseases is needed.
越来越多的证据表明牙周病与各种慢性疾病之间存在关联。可能的解释包括慢性炎症过程、共同的病原体和共同的风险因素，如吸烟和心理社会压力。本研究的目的是评估牙周病与代谢综合征和慢性疾病数量的关联。
作为华盛顿成年人健康调查的一部分，这是一项在 2006-2007 年期间在华盛顿州 25 岁或以上成年人中进行的基于家庭的横断面研究，我们收集了问卷调查数据、血液样本和人体测量数据。我们使用这些数据评估了牙周病与代谢综合征和自我报告的慢性疾病数量之间的关联，控制了年龄、性别、家庭年收入、吸烟和心理社会压力。我们使用了完整病例和多重插补泊松回归分析。
在调整后的完整病例分析中，与无牙周病的人相比，严重牙周病患者的慢性疾病数量增加了 1.4 倍，而严重牙周病患者患代谢综合征的可能性是无牙周病患者的 1.5 倍。关节炎和肝脏疾病与严重牙周病单独相关。多重插补分析的结果相似。
这些结果表明，与无牙周病的人相比，严重牙周病患者更有可能患有更多的慢性疾病，并且更有可能患有代谢综合征。需要研究牙周病治疗的有效性，以帮助预防或控制慢性疾病。
