Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG7 1PB, UK.
Osteoarthritis Cartilage. 2011 Jul;19(7):847-52. doi: 10.1016/j.joca.2011.03.012. Epub 2011 Apr 6.
To determine the community incidence of knee pain and associated risk factors over a 12-year period in people over the age of 40 years.
A cohort study of knee pain was undertaken in 2156 people from four general practices in North Nottinghamshire, UK. Knee pain was defined as 'pain around the knee for most days of at least a month'. Cumulative incidence over 12 years and person-year incidence rate of knee pain were estimated. Survival analysis was undertaken for time to the onset of knee pain. Hazard ratio (HR) and 95% confidence interval (CI) were estimated for relative risk between exposure and non-exposure. Cox regression model was used to adjust for confounding factors.
The 12-year cumulative incidence of knee pain was 34.4% (32% for men and 35% for women), corresponding to an average incidence rate of 32 (31 for men and 34 for women)/1000 person-years. Incident knee pain was associated with female gender (HR 1.27, 95% CI 1.08, 1.49), obesity (1.80; 95% CI 1.37, 2.38), varus (1.68, 95% CI 1.15, 2.47) and valgus (1.83, 95% CI 1.05, 3.20) mal-alignment, and knee injury (2.37, 95% CI 2.98, 2.85).
For people over age 40, one in three will develop knee pain within 12 years. On average, the risk of knee pain was 32/1000 person-years. This risk is associated with a variety of constitutional and environmental biomechanical insults to the knee. Some of these could be modified to possibly reduce the incidence of the condition.
在 12 年内确定 40 岁以上人群膝关节疼痛的社区发病率及其相关危险因素。
对英国诺丁汉郡北部 4 家全科医生诊所的 2156 名人群进行了膝关节疼痛的队列研究。膝关节疼痛定义为“膝关节周围疼痛，持续至少一个月，多数天数都有疼痛”。估计了 12 年内的累积发病率和膝关节疼痛的人年发病率。对膝关节疼痛发病时间进行生存分析。对于暴露与非暴露之间的相对风险，估计了危险比（HR）和 95%置信区间（CI）。使用 Cox 回归模型调整混杂因素。
膝关节疼痛的 12 年累积发病率为 34.4%（男性为 32%，女性为 35%），平均发病率为 32（男性为 31，女性为 34）/1000 人年。新发膝关节疼痛与女性性别（HR 1.27，95%CI 1.08，1.49）、肥胖（1.80；95%CI 1.37，2.38）、内翻（1.68，95%CI 1.15，2.47）和外翻（1.83，95%CI 1.05，3.20）畸形以及膝关节损伤（2.37，95%CI 2.98，2.85）有关。
对于 40 岁以上的人群，每 3 人中就有 1 人在 12 年内会出现膝关节疼痛。平均而言，膝关节疼痛的风险为 32/1000 人年。这种风险与膝关节的各种结构性和环境生物力学损伤有关。其中一些可以进行修改，以可能降低该疾病的发病率。
