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氨基酰-tRNA合成酶对5-氟-2'-脱氧尿苷和5-氟尿苷的糖苷键裂解

Glycosidic bond cleavage of 5-fluoro-2'-deoxyuridine and 5-fluorouridine by amino acyl-tRNA synthetases.

作者信息

Kumar A M, Nayak R

机构信息

Department of Microbiology & Cell Biology, Indian Institute of Science, Bangalore.

出版信息

Biochem Biophys Res Commun. 1990 Dec 14;173(2):731-5. doi: 10.1016/s0006-291x(05)80096-8.

DOI:10.1016/s0006-291x(05)80096-8
PMID:2148086
Abstract

Lysyl-tRNA synthetase isolated from rat liver cleaves glycosidic bond of 5-Fluorouridine and 5-Fluoro-2'-deoxyuridine to generate 5-Fluorouracil. The generation of 5-Fluorouracil was monitored by cellulose thin layer chromatography and by spectrophotometry. The enzyme was found to be 1.4 fold more efficient in cleaving the glycosidic bond of 5-Fluoro-2'-deoxyuridine than 5-Fluorouridine.

摘要

从大鼠肝脏中分离出的赖氨酰 - tRNA合成酶可裂解5 - 氟尿苷和5 - 氟 - 2'-脱氧尿苷的糖苷键，生成5 - 氟尿嘧啶。通过纤维素薄层层析和分光光度法监测5 - 氟尿嘧啶的生成。结果发现，该酶裂解5 - 氟 - 2'-脱氧尿苷糖苷键的效率比裂解5 - 氟尿苷糖苷键的效率高1.4倍。

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