Serikawa Takehiro, Abe Takashi, Minamikawa Takahiro, Itsukaichi Mina, Yamada Kyoko, Saito Tomoko, Kaneko Takayuki, Wada Masaki, Takakuwa Koichi, Tanaka Kenichi
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, Niigata, Japan.
J Obstet Gynaecol Res. 2011 Aug;37(8):1141-4. doi: 10.1111/j.1447-0756.2010.01485.x. Epub 2011 Apr 12.
A 35-year-old Japanese woman in the 24th week of gestation with bilateral breast enlargement was referred to hospital. She was diagnosed with Burkitt's lymphoma and admitted for detailed evaluation and treatment. Early delivery and subsequent chemotherapy was chosen after considering the gestational week, her general condition and the wishes of the patient and her husband. She gave birth to a male infant by cesarean section in the 25(th) week of gestation. It had been planned to begin high-dose chemotherapy, such as CODOX-M/IVAC, on day 7 of the puerperium; however, her general condition worsened and chemotherapy was therefore begun on day 2 after the birth. Eight hours after chemotherapy (cyclophosphamide, vincristine and doxorubicin), she developed cardiac arrest due to tumor lysis syndrome. Despite medical treatment, her bleeding tendency did not improve and she died of respiratory failure with alveolar bleeding five days after chemotherapy.
一名妊娠24周、双侧乳房增大的35岁日本女性被转诊至医院。她被诊断为伯基特淋巴瘤，并入院接受详细评估和治疗。在考虑孕周、她的一般状况以及患者及其丈夫的意愿后，选择了早产并随后进行化疗。她在妊娠25周时通过剖宫产分娩出一名男婴。原本计划在产褥期第7天开始进行大剂量化疗，如CODOX-M/IVAC；然而，她的一般状况恶化，因此在产后第2天开始化疗。化疗（环磷酰胺、长春新碱和阿霉素）8小时后，她因肿瘤溶解综合征发生心脏骤停。尽管进行了治疗，但她的出血倾向并未改善，化疗五天后死于伴有肺泡出血的呼吸衰竭。
