趋化因子与癌症：致命的吸引。
Chemokines and cancer: a fatal attraction.
机构信息
Istituto Clinico Humanitas, IRCCS, I-20089 Rozzano (Milan), Italy.
出版信息
Cancer Cell. 2011 Apr 12;19(4):434-5. doi: 10.1016/j.ccr.2011.03.017.
PMID:21481784
Abstract
Chemokines are important components of cancer-related inflammation. In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and correlates with metastasis in human breast cancer. Unexpectedly, PITPNM3/Nir1, a molecule unrelated to chemokine receptors, was identified as its elusive receptor.
摘要
趋化因子是癌症相关炎症的重要组成部分。在本期《癌细胞》中，Chen 等人报告称，趋化因子 CCL18 由肿瘤相关巨噬细胞产生，可促进恶性行为，并与人类乳腺癌的转移相关。出人意料的是，一种与趋化因子受体无关的分子 PITPNM3/Nir1 被鉴定为其难以捉摸的受体。
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