纳米载体的大小决定了妊娠中的胎盘转运：在大鼠中的研究。
Size of the nanovectors determines the transplacental passage in pregnancy: study in rats.
机构信息
Department of Obstetrics, Gynecology, and Reproductive Medicine, University of Texas Health Science Center at Houston, 77030, USA.
出版信息
Am J Obstet Gynecol. 2011 Jun;204(6):546.e5-9. doi: 10.1016/j.ajog.2011.02.033. Epub 2011 Apr 8.
Abstract
OBJECTIVE
The objective of the study was to examine whether the size of silicon nanovectors (SNVs) inhibits their entrance into the fetal circulation.
STUDY DESIGN
Pregnant rats were intravenously administered with SNVs or saline. The SNVs were spherical particles with 3 escalating diameters: 519 nm, 834 nm, and 1000 nm. The maternal and fetal distribution of SNVs was assessed.
RESULTS
In animals that received 1000 or 834 nm SNV, silicon (Si) levels were significantly higher in the maternal organs vs the saline group, whereas the silicon levels in fetal tissues were similar to controls. However, in animals receiving 519 nm SNVs, fetal silicon levels were significantly higher in the SNV group compared with the saline group (5.93 ± 0.67 μg Si per organ vs 4.80 ± 0.33, P = .01).
CONCLUSION
Larger SNVs do not cross the placenta to the fetus and, remaining within the maternal circulation, can serve as carriers for harmful medications in order to prevent fetal exposure.
摘要
目的
本研究旨在探讨硅纳米载体（SNV）的大小是否会抑制其进入胎儿循环。
研究设计
将 SNV 或生理盐水经静脉注射给怀孕的大鼠。SNV 为具有 3 种递增直径的球形颗粒：519nm、834nm 和 1000nm。评估 SNV 在母鼠和胎鼠中的分布。
结果
在接受 1000nm 或 834nm SNV 的动物中，与生理盐水组相比，硅（Si）在母体器官中的水平显著升高，而胎儿组织中的硅水平与对照组相似。然而，在接受 519nm SNV 的动物中，与生理盐水组相比，SNV 组的胎儿硅水平显著升高（每个器官 5.93±0.67μg Si 与 4.80±0.33，P=0.01）。
结论
较大的 SNV 不会穿过胎盘进入胎儿体内，而是留在母体循环中，可作为有害药物的载体，以防止胎儿暴露。
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本文引用的文献
1
Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation.通过聚乙二醇化来调整介孔硅结构的降解动力学。
J Biomed Mater Res A. 2010 Sep 15;94(4):1236-43. doi: 10.1002/jbm.a.32807.
2
Mitotic trafficking of silicon microparticles.硅微颗粒的有丝分裂运输。
Nanoscale. 2009 Nov;1(2):250-9. doi: 10.1039/b9nr00138g. Epub 2009 Oct 5.
3
Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers.用 PAMAM 树枝状聚合物抑制实验性羊膜绒毛膜炎模型中的细菌生长和羊膜腔内感染
Int J Pharm. 2010 Aug 16;395(1-2):298-308. doi: 10.1016/j.ijpharm.2010.05.030. Epub 2010 May 24.
4
Transport and biodistribution of dendrimers across human fetal membranes: implications for intravaginal administration of dendrimer-drug conjugates.树突状聚合物跨人胎儿膜的转运和分布：对阴道内给予树突状聚合物-药物偶联物的影响。
Biomaterials. 2010 Jun;31(18):5007-21. doi: 10.1016/j.biomaterials.2010.02.075. Epub 2010 Mar 25.
5
Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows.用于增强层流中血管相互作用的纳米/微米颗粒的成型。
Nanotechnology. 2009 Dec 9;20(49):495101. doi: 10.1088/0957-4484/20/49/495101. Epub 2009 Nov 11.
6
The association of silicon microparticles with endothelial cells in drug delivery to the vasculature.硅微粒与内皮细胞在血管给药中的关联。
Biomaterials. 2009 May;30(13):2440-8. doi: 10.1016/j.biomaterials.2009.01.019. Epub 2009 Feb 12.
7
Nanomedicine--challenge and perspectives.纳米医学——挑战与展望。
Angew Chem Int Ed Engl. 2009;48(5):872-97. doi: 10.1002/anie.200802585.
8
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications.介孔硅颗粒作为用于成像和治疗应用的多级递送系统。
Nat Nanotechnol. 2008 Mar;3(3):151-7. doi: 10.1038/nnano.2008.34. Epub 2008 Mar 2.
9
nan'o.tech.nol'o.gy n.纳米技术 名词
Nat Nanotechnol. 2006 Oct;1(1):8-10. doi: 10.1038/nnano.2006.77.
10
Porous silicon in drug delivery devices and materials.药物递送装置及材料中的多孔硅
Adv Drug Deliv Rev. 2008 Aug 17;60(11):1266-1277. doi: 10.1016/j.addr.2008.03.017. Epub 2008 Apr 10.
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