Department of Obstetrics, Gynecology, and Reproductive Medicine, University of Texas Health Science Center at Houston, 77030, USA.
Am J Obstet Gynecol. 2011 Jun;204(6):546.e5-9. doi: 10.1016/j.ajog.2011.02.033. Epub 2011 Apr 8.
The objective of the study was to examine whether the size of silicon nanovectors (SNVs) inhibits their entrance into the fetal circulation.
Pregnant rats were intravenously administered with SNVs or saline. The SNVs were spherical particles with 3 escalating diameters: 519 nm, 834 nm, and 1000 nm. The maternal and fetal distribution of SNVs was assessed.
In animals that received 1000 or 834 nm SNV, silicon (Si) levels were significantly higher in the maternal organs vs the saline group, whereas the silicon levels in fetal tissues were similar to controls. However, in animals receiving 519 nm SNVs, fetal silicon levels were significantly higher in the SNV group compared with the saline group (5.93 ± 0.67 μg Si per organ vs 4.80 ± 0.33, P = .01).
Larger SNVs do not cross the placenta to the fetus and, remaining within the maternal circulation, can serve as carriers for harmful medications in order to prevent fetal exposure.
本研究旨在探讨硅纳米载体（SNV）的大小是否会抑制其进入胎儿循环。
将 SNV 或生理盐水经静脉注射给怀孕的大鼠。SNV 为具有 3 种递增直径的球形颗粒：519nm、834nm 和 1000nm。评估 SNV 在母鼠和胎鼠中的分布。
在接受 1000nm 或 834nm SNV 的动物中，与生理盐水组相比，硅（Si）在母体器官中的水平显著升高，而胎儿组织中的硅水平与对照组相似。然而，在接受 519nm SNV 的动物中，与生理盐水组相比，SNV 组的胎儿硅水平显著升高（每个器官 5.93±0.67μg Si 与 4.80±0.33，P=0.01）。
较大的 SNV 不会穿过胎盘进入胎儿体内，而是留在母体循环中，可作为有害药物的载体，以防止胎儿暴露。
