药物递送装置及材料中的多孔硅
Porous silicon in drug delivery devices and materials.
作者信息
Anglin Emily J, Cheng Lingyun, Freeman William R, Sailor Michael J
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
Jacobs Retina Center at the Shiley Eye Center, Dept of Ophthalmology, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Adv Drug Deliv Rev. 2008 Aug 17;60(11):1266-1277. doi: 10.1016/j.addr.2008.03.017. Epub 2008 Apr 10.
Porous Si exhibits a number of properties that make it an attractive material for controlled drug delivery applications: The electrochemical synthesis allows construction of tailored pore sizes and volumes that are controllable from the scale of microns to nanometers; a number of convenient chemistries exist for the modification of porous Si surfaces that can be used to control the amount, identity, and in vivo release rate of drug payloads and the resorption rate of the porous host matrix; the material can be used as a template for organic and biopolymers, to prepare composites with a designed nanostructure; and finally, the optical properties of photonic structures prepared from this material provide a self-reporting feature that can be monitored in vivo. This paper reviews the preparation, chemistry, and properties of electrochemically prepared porous Si or SiO2 hosts relevant to drug delivery applications.
多孔硅具有许多特性，使其成为用于可控药物递送应用的有吸引力的材料：电化学合成允许构建从微米级到纳米级可控的定制孔径和体积；存在多种用于修饰多孔硅表面的便捷化学方法，可用于控制药物负载的量、种类、体内释放速率以及多孔主体基质的吸收速率；该材料可用作有机和生物聚合物的模板，以制备具有设计纳米结构的复合材料；最后，由这种材料制备的光子结构的光学特性提供了一种可在体内监测的自报告功能。本文综述了与药物递送应用相关的电化学制备的多孔硅或二氧化硅主体的制备、化学性质和特性。
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