Université de Lyon, France.
Curr Opin Immunol. 2011 Jun;23(3):330-6. doi: 10.1016/j.coi.2011.03.004. Epub 2011 Apr 7.
Despite being unable to mount a bona fide recall antibody (Ab) response to secondary immunization, T cell-independent antigens (TI Ag) such as pneumococcal capsular polysaccharides (PS) can generate protective humoral immunity in adults. The concept of TI B cell memory after being iconoclastic for decades has now received experimental support from several laboratories. TI B cell memory comprises two components: i) memory B lymphocytes that differ phenotypically and functionally from their T cell-dependent counterparts, ii) memory bone marrow plasma cells that play a crucial role in the immune protection conferred by TI polysaccharidic vaccines. B-1b cells constitute the major source of both TI memory lymphocytes and plasma cells. This conceptual shift should lead to rehabilitate the TI arm of the immune system for vaccination purposes.
尽管无法对二次免疫产生真正的记忆抗体（Ab）反应，但肺炎球菌荚膜多糖（PS）等 T 细胞非依赖性抗原（TI Ag）可以在成人中产生保护性体液免疫。几十年来一直被视为异端的 TI B 细胞记忆的概念，现在已经得到了几个实验室的实验支持。TI B 细胞记忆由两部分组成：i）表型和功能不同于 T 细胞依赖性的记忆 B 淋巴细胞，ii）在 TI 多糖疫苗赋予的免疫保护中起关键作用的记忆骨髓浆细胞。B-1b 细胞是 TI 记忆淋巴细胞和浆细胞的主要来源。这种概念上的转变应该会促使免疫系统的 TI 分支重新用于疫苗接种。
