Department of Biological Sciences, IBEST, University of Idaho, Moscow, ID 83844-3051, United States.
Curr Opin Struct Biol. 2011 Jun;21(3):441-6. doi: 10.1016/j.sbi.2011.02.005. Epub 2011 Apr 7.
The evolution of disordered proteins or regions of proteins differs from that of ordered proteins because of the differences in their sequence composition, intramolecular contacts, and function. Recent assessments of disordered protein evolution at the sequence, structural, and functional levels support this hypothesis. Disordered proteins have a different pattern of accepted point mutations, exhibit higher rates of insertions and deletions, and generally, but not always, evolve more rapidly than ordered proteins. Even with these high rates of sequence evolution, a few examples have shown that disordered proteins maintain their flexibility under physiological conditions, and it is hypothesized that they maintain specific structural ensembles.
无序蛋白质或蛋白质区域的进化与有序蛋白质的进化不同，这是由于它们在序列组成、分子内接触和功能上的差异。最近在序列、结构和功能水平上对无序蛋白质进化的评估支持了这一假设。无序蛋白质具有不同的可接受点突变模式，表现出更高的插入和缺失率，通常但并非总是比有序蛋白质进化得更快。即使在这些高序列进化率的情况下，也有一些例子表明，无序蛋白质在生理条件下保持其灵活性，并且假设它们保持特定的结构集合。
