帕金森病在瑞典双胞胎中的遗传性：一项纵向研究。
Heritability of Parkinson disease in Swedish twins: a longitudinal study.
机构信息
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
出版信息
Neurobiol Aging. 2011 Oct;32(10):1923.e1-8. doi: 10.1016/j.neurobiolaging.2011.02.017. Epub 2011 Apr 11.
Previous twin studies report no heritability of Parkinson's disease (PD) based on cross sectional information. Here, we apply a longitudinal design and re-evaluate cross sectional data in the population-based Swedish Twin Registry (STR) using clinical as well as hospital discharge and cause of death diagnoses. In the longitudinal analyses (based on 46,436 individuals), we identified 542 twins with PD and 65 twins with Parkinsonism. Concordance rates for PD were 11% for monozygotic and 4% for same-sexed dizygotic twin pairs, with a heritability estimate of 34%. Concordance rates for PD or parkinsonism were 13% for monozygotic and 5% for same-sexed dizygotic twin pairs, with a heritability estimate of 40%. In the cross sectional analyses (based on 49,814 individuals), we identified 287 twins with PD and 79 twins with parkinsonism. Concordance rates for PD were 4% for monozygotic and same-sexed dizygotic twin pairs and 0 for opposite-sexed twin pairs. Concordance rates for PD or parkinsonism were somewhat higher but the heritability estimate was nonsignificant. Our longitudinal analyses demonstrate that PD and parkinsonism are modestly heritable.
先前的双胞胎研究报告基于横断面信息，帕金森病（PD）没有遗传性。在这里，我们应用纵向设计，重新评估基于人群的瑞典双胞胎登记处（STR）中的横断面数据，使用临床以及住院和死因诊断。在纵向分析中（基于 46436 个人），我们确定了 542 对患有 PD 的双胞胎和 65 对患有帕金森症的双胞胎。同卵双胞胎的 PD 一致性率为 11%，同性别异卵双胞胎的 PD 一致性率为 4%，遗传率估计为 34%。PD 或帕金森症的一致性率为同卵双胞胎的 13%和同性别异卵双胞胎的 5%，遗传率估计为 40%。在横断面分析中（基于 49814 个人），我们确定了 287 对患有 PD 的双胞胎和 79 对患有帕金森症的双胞胎。同卵双胞胎的 PD 一致性率为 4%，同性别异卵双胞胎的 PD 一致性率为 0%，而异性双胞胎的 PD 一致性率为 0%。PD 或帕金森症的一致性率略高，但遗传率估计无统计学意义。我们的纵向分析表明，PD 和帕金森症具有中等程度的遗传性。
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