Division of Occupational and Environmental Medicine; University of California-San Francisco, San Francisco Veterans Affairs Health Care System, University of California-San Francisco, San Francisco, CA.
Institute for Neurodegenerative Disorders, New Haven, CT.
Ann Neurol. 2019 Apr;85(4):600-605. doi: 10.1002/ana.25441. Epub 2019 Mar 11.
During the 1990s, we estimated the genetic contribution to Parkinson's disease risk in a large, population-based twin registry. Because many unaffected twins were still alive, previous concordance estimates were based on incomplete information. Ninety-five percent of twins are now deceased. Here, we update concordance and heritability through 2015 using National Death Index data. In total, we identified 30 concordant and 193 discordant pairs. Proband-wise concordance was 0.20 in monozygotic and 0.13 in dizygotic pairs. Heritability was 0.27 overall, 0.83 in pairs diagnosed ≤50, and 0.19 in pairs diagnosed >50. High concordance in dizygotic twins suggests shared effects of early childhood environment. Ann Neurol 2019;85:600-605.
20 世纪 90 年代，我们在一个大型基于人群的双胞胎登记处估算了帕金森病风险的遗传贡献。由于许多未受影响的双胞胎仍然在世，先前的一致性估计是基于不完整的信息。现在 95%的双胞胎已经去世。在这里，我们使用国家死亡索引数据更新了 2015 年的一致性和遗传性。总共确定了 30 对一致和 193 对不一致的双胞胎。在单卵双胞胎中，先证者一致性为 0.20，在双卵双胞胎中为 0.13。总体而言，遗传性为 0.27，在≤50 岁诊断的双胞胎中为 0.83，在>50 岁诊断的双胞胎中为 0.19。双卵双胞胎的高度一致性表明存在儿童早期环境的共同影响。神经病学年鉴 2019;85:600-605。
