Mehr Ramit, Melamed Doron
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Aging (Albany NY). 2011 Apr;3(4):438-43. doi: 10.18632/aging.100313.
Age-related alterations in the cellular composition of the B lineage are a major cause of the poor antibody response to vaccination and to infectious agents among the elderly population. The mechanisms leading to these changes are poorly understood. Recently, we have shown that these changes reflect, at least in part, homeostatic pressures imposed by long-lived B cells that accumulate with aging, and that aging in the B lineage can be reversed upon alteration of B cell homeostasis by depletion. Here we discuss homeostatic causes for B lineage immunosenescence, and the potential for its rejuvenation.
B细胞谱系细胞组成的年龄相关改变是老年人群对疫苗接种和感染因子抗体反应不佳的主要原因。导致这些变化的机制尚不清楚。最近，我们已经表明，这些变化至少部分反映了随着年龄增长而积累的长寿B细胞施加的稳态压力，并且通过消耗改变B细胞稳态后，B细胞谱系的衰老可以逆转。在这里，我们讨论B细胞谱系免疫衰老的稳态原因及其恢复活力的潜力。
