Wanner Samuel P, Garami Andras, Romanovsky Andrej A
Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.
Aging (Albany NY). 2011 Apr;3(4):450-4. doi: 10.18632/aging.100306.
We have recently found that, at a young age, transient receptor potential vanilloid-1 (Trpv1) knockout (-/-) mice have a higher locomotor activity than their wild-type littermates (+/+). We have also found that, with age, Trpv1(-/-) mice become substantially heavier than Trpv1(+/+) controls, thus forming a paradoxical association between locomotor hyperactivity and overweight. The present study solves this contradiction. By using two experimental paradigms, we show that aged Trpv1(-/-) mice have not an increased, but a decreased, locomotor activity, as compared to age-matched Trpv1(+/+) controls. We also confirm that aged Trpv1(-/-) mice are overweight. We conclude that TRPV1 channels are involved in the regulation of both general locomotor activity and body mass in an age-dependent manner.
我们最近发现，幼年时，瞬时受体电位香草酸亚型1（Trpv1）基因敲除（-/-）小鼠比其野生型同窝小鼠（+/+）具有更高的运动活性。我们还发现，随着年龄增长，Trpv1（-/-）小鼠比Trpv1（+/+）对照小鼠明显更重，从而在运动亢进与超重之间形成了一种矛盾的关联。本研究解决了这一矛盾。通过使用两种实验范式，我们表明，与年龄匹配的Trpv1（+/+）对照小鼠相比，老年Trpv1（-/-）小鼠的运动活性并未增加，反而降低。我们还证实老年Trpv1（-/-）小鼠超重。我们得出结论，TRPV1通道以年龄依赖的方式参与一般运动活性和体重的调节。
