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2010年至2012年从一家三级医院临床标本中分离出的金黄色葡萄球菌的抗生素耐药性分析

Antibiotic Resistance Profiling of Staphylococcus aureus Isolated from Clinical Specimens in a Tertiary Hospital from 2010 to 2012.

作者信息

Juayang Alain C, de Los Reyes Gemma B, de la Rama April Joy G, Gallega Christine T

机构信息

Dr. Pablo O. Torre Memorial Hospital, 6100 Bacolod, Philippines ; Colegio San Agustin, 6100 Bacolod, Philippines.

Colegio San Agustin, 6100 Bacolod, Philippines.

出版信息

Interdiscip Perspect Infect Dis. 2014;2014:898457. doi: 10.1155/2014/898457. Epub 2014 Sep 3.

Abstract

MRSA infection can affect a wide array of individuals that may lead to treatment failure. Also, the infection has the potential to spread from one area to another particularly health care facilities or communities eventually causing minor outbreaks. With this premise, the study aimed to describe MRSA infections using the hospital-based data of a tertiary hospital in Bacolod City, Philippines, from 2010 to 2012. Specifically, this study aimed to evaluate the antimicrobial resistance of S. aureus isolated from clinical specimens and to put emphasis on the prevalence of MRSA and Inducible Clindamycin Resistance. A total of 94 cases from 2010 to 2012 were diagnosed to have S. aureus infection using conventional bacteriologic methods. From these cases, 38 (40.6%) were identified as MRSA and 37 (39.4%) were inducible clindamycin resistant. Wounds and abscesses were considered to be the most common specimens with MRSA infections having 71.05% while blood was the least with 5.3%. For drug susceptibility, out of the 94 S. aureus cases, including MRSA, 100% were susceptible to linezolid making it the drug of choice for this study. It was then followed by tetracycline having a mean susceptibility of 95%;, while penicillin G was ineffective with 94 cases having 0% susceptibility.

摘要

耐甲氧西林金黄色葡萄球菌(MRSA)感染可影响众多个体,可能导致治疗失败。此外,这种感染有可能从一个区域传播到另一个区域,尤其是在医疗保健机构或社区,最终引发小规模疫情。基于这一前提,本研究旨在利用菲律宾巴科洛德市一家三级医院2010年至2012年的医院数据来描述MRSA感染情况。具体而言,本研究旨在评估从临床标本中分离出的金黄色葡萄球菌的抗菌耐药性,并重点关注MRSA和诱导型克林霉素耐药的患病率。2010年至2012年期间,共有94例病例通过传统细菌学方法被诊断为金黄色葡萄球菌感染。在这些病例中,38例(40.6%)被鉴定为MRSA,37例(39.4%)为诱导型克林霉素耐药。伤口和脓肿被认为是MRSA感染最常见的标本,占71.05%,而血液标本最少,占5.3%。对于药敏试验,在94例金黄色葡萄球菌病例(包括MRSA)中,100%对利奈唑胺敏感,使其成为本研究的首选药物。其次是四环素,平均药敏率为95%;而青霉素G无效,94例病例的药敏率为0%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8622/4167206/ae71359d32cb/IPID2014-898457.001.jpg

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