Department of Physics, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Biomicrofluidics. 2011 Mar 16;5(1):14107. doi: 10.1063/1.3567093.
We present a simple method for creating monodisperse emulsions with microfluidic devices. Unlike conventional approaches that require bulky pumps, control computers, and expertise with device physics to operate devices, our method requires only the microfluidic device and a hand-operated syringe. The fluids needed for the emulsion are loaded into the device inlets, while the syringe is used to create a vacuum at the device outlet; this sucks the fluids through the channels, generating the drops. By controlling the hydrodynamic resistances of the channels using hydrodynamic resistors and valves, we are able to control the properties of the drops. This provides a simple and highly portable method for creating monodisperse emulsions.
我们提出了一种使用微流控装置制备单分散乳液的简单方法。与传统方法需要庞大的泵、控制计算机以及对设备物理特性的专业知识来操作设备不同,我们的方法只需要微流控设备和手动注射器。乳液所需的流体被装入设备入口,而注射器用于在设备出口处产生真空;这会将流体吸入通道,生成液滴。通过使用流体阻力器和阀门来控制通道的流体阻力,我们能够控制液滴的性质。这为制备单分散乳液提供了一种简单且高度便携的方法。