Department of Chemistry , Yale University , 225 Prospect Street , New Haven , Connecticut 06520-8107 , United States.
J Am Chem Soc. 2019 Apr 10;141(14):5669-5674. doi: 10.1021/jacs.9b02552. Epub 2019 Mar 25.
We herein disclose the first report of a first-row transition metal-catalyzed α,β-dehydrogenation of carbonyl compounds using allyl-nickel catalysis. This development overcomes several limitations of previously reported allyl-palladium-catalyzed oxidation, and is further leveraged for the development of an oxidative cycloalkenylation reaction that provides access to bicycloalkenones with fused, bridged, and spirocyclic ring systems using unactivated ketone and alkene precursors.
我们在此披露了首例使用烯丙基-镍催化的第一过渡金属催化的羰基化合物的α,β-脱氢反应。这一发展克服了先前报道的烯丙基-钯催化氧化的几个限制,并进一步被用于开发氧化环烯化反应,该反应使用未活化的酮和烯烃前体,为具有稠合、桥连和螺环体系的双环烯酮提供了途径。