抑制神经节苷脂生物合成作为胰岛素抵抗的一种新型治疗方法。
Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance.
作者信息
Inokuchi Jin-Ichi
机构信息
Division of Glycopathology and CREST, Japan.
出版信息
Handb Exp Pharmacol. 2011(203):165-78. doi: 10.1007/978-3-642-17214-4_8.
PMID:21484572
Abstract
A new concept "Life style-related diseases, such as type 2 diabetes, are a membrane microdomain disorder caused by aberrant expression of gangliosides" has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains microdomains and propose the new therapeutic strategy "membrane microdomain ortho-signaling therapy".
摘要
一个新的概念“与生活方式相关的疾病，如2型糖尿病，是由神经节苷脂异常表达引起的膜微区紊乱”已经出现。通过研究这个工作假设，我们聚焦于微区中胰岛素受体与神经节苷脂之间的相互作用，阐述了2型糖尿病和胰岛素抵抗的分子发病机制，并提出了新的治疗策略“膜微区正信号疗法”。
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