GM3与糖尿病
GM3 and diabetes.
作者信息
Inokuchi Jin-ichi
机构信息
Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1, komatsushima, Aoba-ku, Sendai, 981-8558, Miyagi, Japan,
出版信息
Glycoconj J. 2014 Apr;31(3):193-7. doi: 10.1007/s10719-013-9516-4. Epub 2014 Jan 8.
We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides". It is expected that the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy "membrane microdomain ortho-signaling therapy".
我们聚焦于脂肪细胞中胰岛素受体与GM3神经节苷脂之间的相互作用，阐述了2型糖尿病和胰岛素抵抗的分子发病机制，并提出了一个工作假说：“诸如2型糖尿病之类的代谢紊乱是由神经节苷脂异常表达引起的膜微区紊乱”。通过鉴定特定的神经节苷脂种类来开发新型代谢综合征诊断方法以及“膜微区正信号疗法”这一治疗策略有望实现。
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