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p16表达在爱泼斯坦-巴尔病毒阳性鼻咽癌中的预后价值

Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas.

作者信息

Jiang Wen, Chamberlain Paul D, Garden Adam S, Kim Betty Y S, Ma Dominic, Lo Emily J, Bell Diana, Gunn G Brandon, Fuller Clifton D, Rosenthal David I, Beadle Beth M, Frank Steven J, Morrison William H, El-Naggar Adel K, Glisson Bonnie S, Sturgis Erich M, Phan Jack

机构信息

Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.

Department of Cancer Biology, Neurosurgery, Mayo Clinic, Jacksonville, Florida.

出版信息

Head Neck. 2016 Apr;38 Suppl 1(Suppl 1):E1459-66. doi: 10.1002/hed.24258. Epub 2015 Nov 11.

DOI:10.1002/hed.24258
PMID:26560893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5903429/
Abstract

BACKGROUND

Overexpression of p16 is associated with improved outcomes among patients with oropharyngeal carcinoma. However, its role in the outcomes of patients with nasopharyngeal cancer (NPC) remains unclear.

METHODS

Eighty-six patients with NPC treated at MD Anderson Cancer Center from 2000 to 2014 were identified. Epstein-Barr virus (EBV) and human papillomavirus (HPV) status were determined by in situ hybridization (ISH) and p16 by immunohistochemical staining.

RESULTS

EBV positivity was associated with extended overall survival (OS; median, 95.0 vs 44.9 months; p < .004), progression-free survival (PFS; median, 80.4 vs 28.1 months; p < .013), and locoregional control (median, 104.4 vs 65.5 months; p < .043). In patients with EBV-positive tumors, p16 overexpression correlated with improved PFS (median, 106.3 vs 27.1 months; p < .02) and locoregional control (median, 93.6 vs 64.5 months; p < .02).

CONCLUSION

P16 overexpression is associated with improved PFS and locoregional control in patients with EBV-positive NPC. P16 expression may complement EBV status in predicting treatment outcomes for patients with NPC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1459-E1466, 2016.

摘要

背景

p16过表达与口咽癌患者预后改善相关。然而，其在鼻咽癌（NPC）患者预后中的作用仍不明确。

方法

确定了2000年至2014年在MD安德森癌症中心接受治疗的86例NPC患者。通过原位杂交（ISH）确定爱泼斯坦-巴尔病毒（EBV）和人乳头瘤病毒（HPV）状态，通过免疫组织化学染色确定p16状态。

结果

EBV阳性与总生存期（OS）延长相关（中位数，95.0对44.9个月；p < 0.004）、无进展生存期（PFS）延长相关（中位数，80.4对28.1个月；p < 0.013）和局部区域控制相关（中位数，104.4对65.5个月；p < 0.043）。在EBV阳性肿瘤患者中，p16过表达与PFS改善相关（中位数，106.3对27.1个月；p < 0.02）和局部区域控制相关（中位数，93.6对64.5个月；p < 0.02）。

结论

p16过表达与EBV阳性NPC患者的PFS改善和局部区域控制相关。p16表达可能在预测NPC患者治疗结果方面补充EBV状态。©2015威利期刊公司。头颈外科38：E1459 - E1466，2016年。

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2
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3
Oncogenic human papillomavirus-associated nasopharyngeal carcinoma: an observational study of correlation with ethnicity, histological subtype and outcome in a UK population.人乳头瘤病毒相关性鼻咽癌：英国人群中与种族、组织学亚型和结局相关性的观察性研究。
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4
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Head Neck. 2014 May;36(5):709-14. doi: 10.1002/hed.23362. Epub 2013 Oct 26.
5
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6
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7
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Lancet Oncol. 2012 Feb;13(2):163-71. doi: 10.1016/S1470-2045(11)70320-5. Epub 2011 Dec 7.
8
LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis.LMP1 表达与鼻咽癌转移呈正相关：来自荟萃分析的证据。
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