• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

p16表达在爱泼斯坦-巴尔病毒阳性鼻咽癌中的预后价值

Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas.

作者信息

Jiang Wen, Chamberlain Paul D, Garden Adam S, Kim Betty Y S, Ma Dominic, Lo Emily J, Bell Diana, Gunn G Brandon, Fuller Clifton D, Rosenthal David I, Beadle Beth M, Frank Steven J, Morrison William H, El-Naggar Adel K, Glisson Bonnie S, Sturgis Erich M, Phan Jack

机构信息

Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.

Department of Cancer Biology, Neurosurgery, Mayo Clinic, Jacksonville, Florida.

出版信息

Head Neck. 2016 Apr;38 Suppl 1(Suppl 1):E1459-66. doi: 10.1002/hed.24258. Epub 2015 Nov 11.

DOI:10.1002/hed.24258
PMID:26560893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5903429/
Abstract

BACKGROUND

Overexpression of p16 is associated with improved outcomes among patients with oropharyngeal carcinoma. However, its role in the outcomes of patients with nasopharyngeal cancer (NPC) remains unclear.

METHODS

Eighty-six patients with NPC treated at MD Anderson Cancer Center from 2000 to 2014 were identified. Epstein-Barr virus (EBV) and human papillomavirus (HPV) status were determined by in situ hybridization (ISH) and p16 by immunohistochemical staining.

RESULTS

EBV positivity was associated with extended overall survival (OS; median, 95.0 vs 44.9 months; p < .004), progression-free survival (PFS; median, 80.4 vs 28.1 months; p < .013), and locoregional control (median, 104.4 vs 65.5 months; p < .043). In patients with EBV-positive tumors, p16 overexpression correlated with improved PFS (median, 106.3 vs 27.1 months; p < .02) and locoregional control (median, 93.6 vs 64.5 months; p < .02).

CONCLUSION

P16 overexpression is associated with improved PFS and locoregional control in patients with EBV-positive NPC. P16 expression may complement EBV status in predicting treatment outcomes for patients with NPC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1459-E1466, 2016.

摘要

背景

p16过表达与口咽癌患者预后改善相关。然而，其在鼻咽癌（NPC）患者预后中的作用仍不明确。

方法

确定了2000年至2014年在MD安德森癌症中心接受治疗的86例NPC患者。通过原位杂交（ISH）确定爱泼斯坦-巴尔病毒（EBV）和人乳头瘤病毒（HPV）状态，通过免疫组织化学染色确定p16状态。

结果

EBV阳性与总生存期（OS）延长相关（中位数，95.0对44.9个月；p < 0.004）、无进展生存期（PFS）延长相关（中位数，80.4对28.1个月；p < 0.013）和局部区域控制相关（中位数，104.4对65.5个月；p < 0.043）。在EBV阳性肿瘤患者中，p16过表达与PFS改善相关（中位数，106.3对27.1个月；p < 0.02）和局部区域控制相关（中位数，93.6对64.5个月；p < 0.02）。

结论

p16过表达与EBV阳性NPC患者的PFS改善和局部区域控制相关。p16表达可能在预测NPC患者治疗结果方面补充EBV状态。©2015威利期刊公司。头颈外科38：E1459 - E1466，2016年。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/5903429/80267294667a/nihms719873f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/5903429/b7f20a871a54/nihms719873f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/5903429/80267294667a/nihms719873f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/5903429/b7f20a871a54/nihms719873f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/5903429/80267294667a/nihms719873f2.jpg

相似文献

1
Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas.p16表达在爱泼斯坦-巴尔病毒阳性鼻咽癌中的预后价值
Head Neck. 2016 Apr;38 Suppl 1(Suppl 1):E1459-66. doi: 10.1002/hed.24258. Epub 2015 Nov 11.
2
Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan.爱泼斯坦-巴尔病毒及p16状态在鼻咽癌患者中的临床价值：日本一项单中心研究
ORL J Otorhinolaryngol Relat Spec. 2016;78(6):334-343. doi: 10.1159/000455901. Epub 2017 Feb 8.
3
Expression of Epstein-Barr virus-encoded latent membrane protein (LMP-1), p16 and p53 proteins in nonendemic nasopharyngeal carcinoma (NPC): a clinicopathological study.非流行地区鼻咽癌中 EB 病毒编码的潜伏膜蛋白（LMP-1）、p16 和 p53 蛋白的表达：一项临床病理研究。
Arch Med Res. 2014 Apr;45(3):229-36. doi: 10.1016/j.arcmed.2014.02.002. Epub 2014 Mar 4.
4
Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein-Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines.菲律宾患者鼻咽癌中程序性死亡配体1表达、微卫星不稳定性、爱泼斯坦-巴尔病毒和人乳头瘤病毒情况
Head Neck Pathol. 2017 Jun;11(2):203-211. doi: 10.1007/s12105-016-0765-y. Epub 2016 Nov 2.
5
Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population.低发人群鼻咽癌中的人乳头瘤病毒和爱泼斯坦-巴尔病毒
Head Neck. 2014 Apr;36(4):511-6. doi: 10.1002/hed.23318. Epub 2013 Jun 18.
6
Pretreatment Serum Amyloid A and C-reactive Protein Comparing with Epstein-Barr Virus DNA as Prognostic Indicators in Patients with Nasopharyngeal Carcinoma: A Prospective Study.治疗前血清淀粉样蛋白 A 和 C 反应蛋白与 Epstein-Barr 病毒 DNA 作为鼻咽癌患者预后指标的比较：一项前瞻性研究。
Cancer Res Treat. 2018 Jul;50(3):701-711. doi: 10.4143/crt.2017.180. Epub 2017 Jul 14.
7
Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis.通过cDNA微阵列和基因集富集分析鉴定爱泼斯坦-巴尔病毒相关鼻咽癌中异常的细胞周期调控
Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):414-28. doi: 10.1093/abbs/gmp025.
8
The diagnostic and prognostic values of plasma Epstein-Barr virus DNA for residual cervical lymphadenopathy in nasopharyngeal carcinoma patients: a retrospective study.血浆 Epstein-Barr 病毒 DNA 对鼻咽癌患者残留颈淋巴结转移的诊断和预后价值：一项回顾性研究。
Cancer Commun (Lond). 2019 Mar 29;39(1):14. doi: 10.1186/s40880-019-0357-9.
9
Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma: A nationwide study in Finland.爱泼斯坦-巴尔病毒和人乳头瘤病毒作为鼻咽癌的有利预后因素：芬兰的一项全国性研究。
Head Neck. 2019 Feb;41(2):349-357. doi: 10.1002/hed.25450. Epub 2018 Dec 14.
10
Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis.非流行型 HPV 阳性鼻咽癌：与不良预后相关。
Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):580-8. doi: 10.1016/j.ijrobp.2013.11.246.

引用本文的文献

1
Patient Characteristics and Treatment Outcomes of Nasopharyngeal Carcinoma in Nonendemic Regions.非流行地区鼻咽癌的患者特征及治疗结果
JAMA Netw Open. 2025 Mar 3;8(3):e251895. doi: 10.1001/jamanetworkopen.2025.1895.
2
Epithelial‑derived head and neck squamous tumourigenesis (Review).上皮来源的头颈部鳞状肿瘤发生（综述）。
Oncol Rep. 2024 Oct;52(4). doi: 10.3892/or.2024.8800. Epub 2024 Sep 2.
3
Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland.

本文引用的文献

1
Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis.非流行型 HPV 阳性鼻咽癌：与不良预后相关。
Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):580-8. doi: 10.1016/j.ijrobp.2013.11.246.
2
Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review.口咽肿瘤中人类乳头瘤病毒与 p16 过表达的相关性：系统评价。
Br J Cancer. 2014 Mar 18;110(6):1587-94. doi: 10.1038/bjc.2014.42. Epub 2014 Feb 11.
3
Oncogenic human papillomavirus-associated nasopharyngeal carcinoma: an observational study of correlation with ethnicity, histological subtype and outcome in a UK population.
在一例 EBV 相关涎腺淋巴上皮癌中，针对 HER2、p16 和生长抑素受体 2 表达的肿瘤异质性挑战。
Head Neck Pathol. 2023 Dec;17(4):1052-1057. doi: 10.1007/s12105-023-01592-4. Epub 2023 Oct 17.
4
The Clinical Characteristics and Outcomes of Human Papillomavirus-Positive Nasopharyngeal Carcinoma in a Single-Institution Cohort.单机构队列中人乳头瘤病毒阳性鼻咽癌的临床特征与预后
J Clin Med. 2023 Jun 25;12(13):4264. doi: 10.3390/jcm12134264.
5
p16 and pRb expression in laryngeal squamous cell carcinoma with and without infection by EBV or different genotypes of HPV: a retrospective study.伴有或不伴有EBV感染或不同基因型HPV感染的喉鳞状细胞癌中p16和pRb的表达：一项回顾性研究
Infect Agent Cancer. 2023 Jul 11;18(1):43. doi: 10.1186/s13027-023-00514-x.
6
Impact of P16 Positivity on Clinical Outcomes in Nasopharyngeal Carcinoma: A Single Institution Study.P16 阳性对鼻咽癌临床结局的影响：一项单机构研究
Cureus. 2023 Feb 22;15(2):e35308. doi: 10.7759/cureus.35308. eCollection 2023 Feb.
7
Association of human papillomavirus and Epstein-Barr virus with squamous cell carcinoma of upper aerodigestive tract.人乳头瘤病毒和爱泼斯坦-巴尔病毒与上消化道鳞状细胞癌的关联
Natl J Maxillofac Surg. 2022 Sep-Dec;13(3):367-375. doi: 10.4103/njms.njms_315_21. Epub 2022 Dec 10.
8
A Survey of Human Papillomavirus and Epstein-Barr virus Immunohistochemical Status in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC).人乳头瘤病毒和 Epstein-Barr 病毒免疫组织化学状态在头颈部鳞状细胞癌（HNSCC）患者中的调查。
Head Neck Pathol. 2023 Jun;17(2):325-330. doi: 10.1007/s12105-022-01483-0. Epub 2022 Oct 27.
9
High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis.高危型人乳头瘤病毒与爱泼斯坦-巴尔病毒共感染：在头颈部肿瘤发生中的潜在作用
Biology (Basel). 2021 Nov 26;10(12):1232. doi: 10.3390/biology10121232.
10
Survival Outcomes in Human Papillomavirus-Associated Nonoropharyngeal Squamous Cell Carcinomas: A Systematic Review and Meta-analysis.人乳头瘤病毒相关非口咽鳞状细胞癌的生存结局：系统评价和荟萃分析。
JAMA Otolaryngol Head Neck Surg. 2020 Dec 1;146(12):1158-1166. doi: 10.1001/jamaoto.2020.3382.
人乳头瘤病毒相关性鼻咽癌：英国人群中与种族、组织学亚型和结局相关性的观察性研究。
Infect Agent Cancer. 2013 Aug 12;8(1):30. doi: 10.1186/1750-9378-8-30.
4
Human papillomavirus 16 detected in nasopharyngeal carcinomas in white Americans but not in endemic Southern Chinese patients.在美籍白人的鼻咽癌中检测到了人乳头瘤病毒16型，但在中国南方鼻咽癌高发地区的患者中未检测到。
Head Neck. 2014 May;36(5):709-14. doi: 10.1002/hed.23362. Epub 2013 Oct 26.
5
Promising treatment outcomes of intensity-modulated radiation therapy for nasopharyngeal carcinoma patients with N0 disease according to the seventh edition of the AJCC staging system.根据第七版 AJCC 分期系统，调强放疗治疗 N0 期鼻咽癌患者的治疗效果令人鼓舞。
BMC Cancer. 2012 Feb 15;12:68. doi: 10.1186/1471-2407-12-68.
6
p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency.p16 表达作为 HPV 相关口咽癌的替代标志物：解释相关性和一致性的指南。
Head Neck. 2012 Apr;34(4):459-61. doi: 10.1002/hed.21974. Epub 2011 Dec 16.
7
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial.同期放化疗加辅助化疗与单纯同期放化疗治疗局部晚期鼻咽癌患者的随机对照 3 期多中心临床试验。
Lancet Oncol. 2012 Feb;13(2):163-71. doi: 10.1016/S1470-2045(11)70320-5. Epub 2011 Dec 7.
8
LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis.LMP1 表达与鼻咽癌转移呈正相关：来自荟萃分析的证据。
J Clin Pathol. 2012 Jan;65(1):41-5. doi: 10.1136/jclinpath-2011-200198. Epub 2011 Oct 29.
9
High-risk human papillomavirus in nasopharyngeal carcinoma.高危型人乳头瘤病毒与鼻咽癌。
Head Neck. 2012 Feb;34(2):213-8. doi: 10.1002/hed.21714. Epub 2011 Apr 11.
10
p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells.p38MAPK 和 JNK 拮抗作用控制阿霉素处理的内皮祖细胞衰老和细胞质 p16INK4A 的表达。
PLoS One. 2010 Dec 20;5(12):e15583. doi: 10.1371/journal.pone.0015583.