Hung Shih-Han, Yang Tzong-Hann, Cheng Yen-Fu, Chen Chin-Shyan, Lin Herng-Ching
Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Department of Otolaryngology, Wan Fang Hospital, Taipei 110, Taiwan.
Cancers (Basel). 2023 Aug 13;15(16):4082. doi: 10.3390/cancers15164082.
This population-based study aims to examine the association between nasopharyngeal carcinoma and human papillomavirus infections. This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivariate logistic regression models were employed to quantitatively assess the association of nasopharynx cancer with human papillomavirus infections while considering age, sex, monthly income, geographic location, and urbanization level of the patient's residence as well as diabetes, hypertension, and hyperlipidemia. Our chi-squared test indicated a significant dissimilarity in previous human papillomavirus infection rates between nasopharynx cancer patients and controls (12.7% vs. 7.2%, < 0.001). The adjusted odds ratio (OR) for prior human papillomavirus infections was found to be significantly higher for nasopharyngeal carcinoma cases compared to controls at a value of 1.869 with confidence interval ranging from 1.640 to 2.128. Among female participants, compared to controls, the adjusted OR of prior human papillomavirus infections was 2.150 (95% CI = 1.763-2.626) in patients with nasopharynx cancer. In male participants sampled in this study, we observed a statistically significant association between prior human papillomavirus infections and nasopharynx cancer (adjusted OR = 1.689; 95% CI = 1.421-2.008). Our study indicates a noteworthy association between previous human papillomavirus infections and nasopharyngeal carcinoma.
这项基于人群的研究旨在探讨鼻咽癌与人类乳头瘤病毒感染之间的关联。该研究纳入了2747名20岁及以上被诊断为鼻咽癌的个体作为病例组，以及13735名倾向得分匹配的对照组。采用多变量逻辑回归模型，在考虑患者居住地的年龄、性别、月收入、地理位置和城市化水平以及糖尿病、高血压和高脂血症的情况下，定量评估鼻咽癌与人类乳头瘤病毒感染之间的关联。我们的卡方检验表明，鼻咽癌患者与对照组之前的人类乳头瘤病毒感染率存在显著差异（12.7%对7.2%，<0.001）。结果发现，与对照组相比，鼻咽癌病例之前人类乳头瘤病毒感染的调整优势比（OR）显著更高，为1.869，置信区间为1.640至2.128。在女性参与者中，与对照组相比，鼻咽癌患者之前人类乳头瘤病毒感染的调整OR为2.150（95%CI = 1.763 - 2.626）。在本研究抽样的男性参与者中，我们观察到之前的人类乳头瘤病毒感染与鼻咽癌之间存在统计学上的显著关联（调整OR = 1.689；95%CI = 1.421 - 2.008）。我们的研究表明，之前的人类乳头瘤病毒感染与鼻咽癌之间存在显著关联。
