Shaari Khozirah, Zareen Seema, Akhtar Muhammad Nadeem, Lajis Nordin Hj
Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor.
Nat Prod Commun. 2011 Mar;6(3):343-8.
Phytochemical investigations on the methanolic extract of Melicope ptelefolia Champ ex Benth. resulted in the isolation of three new compounds, identified as 3beta-stigmast-5-en-3-ol butyl tridecanedioate (melicoester) (1), (2Z, 6Z, 10Z, 14Z, 18Z, 22Z, 26E)-3', 7', 11', 15', 19', 23', 27', 31'-octamethyldotriaconta-2, 6, 10, 14, 18, 22, 26, 30-octadecanoate (melicopeprenoate) (2) and p-O-geranyl-7"-acetoxy coumaric acid (3). The compounds were isolated along with twenty-one other known compounds, lupeol (4), oleanolic acid (5), kokusaginine (6) genistein (7), p-O-geranyl coumaric acid (8), 4-stigmasten-3-one (9), 3beta-hydroxystigma-5-en-7-one (10) cis-phytyl palmitate (11), dodecane, dodecan-1-ol, ceryl alcohol, hentriacontanoic acid, eicosane, n-amyl alcohol, caprylic alcohol, octatriacontane, nonatriacontane, hexatriencontan-1-ol, methyl octacosanoate, beta-sitosterol, beta-sitosterol glucoside. Structures of all the compounds were established on the basis of MS and 1D and 2D NMR spectral data, as well as comparison with reported data.
对山椒叶蜜茱萸（Melicope ptelefolia Champ ex Benth.）甲醇提取物进行的植物化学研究，分离出了三种新化合物，分别鉴定为3β-豆甾-5-烯-3-醇十三烷二酸丁酯（蜜茱萸酯）（1）、（2Z, 6Z, 10Z, 14Z, 18Z, 22Z, 26E）-3', 7', 11', 15', 19', 23', 27', 31'-八甲基三十二碳-2, 6, 10, 14, 18, 22, 26, 30-十八烯酸酯（蜜茱萸异戊二烯酸酯）（2）和对-O-香叶基-7''-乙酰氧基香豆酸（3）。这些化合物与其他二十一种已知化合物一起被分离出来，包括羽扇豆醇（4）、齐墩果酸（5）、非洲防己碱（6）、染料木素（7）、对-O-香叶基香豆酸（8）、4-豆甾烯-3-酮（9）、3β-羟基豆甾-5-烯-7-酮（10）、顺式植醇棕榈酸酯（11）、十二烷、十二醇、蜡醇、三十一烷酸（正三十一烷酸）、二十烷、正戊醇、辛醇、三十八烷、三十九烷、六十碳六烯醇、二十八烷酸甲酯、β-谷甾醇、β-谷甾醇葡萄糖苷。所有化合物的结构均通过质谱、一维和二维核磁共振光谱数据以及与已报道数据的比较得以确定。
