Pharmaceutics Division, Central Drug Research Institute, (Council of Scientific and Industrial Research, India), P.O. Box 173, M.G. Marg, Lucknow 226001, India.
J Biomed Nanotechnol. 2011 Feb;7(1):47-9. doi: 10.1166/jbn.2011.1195.
A ciprofloxacin (CFn)-loaded lipid emulsion was developed for treatment of intra-abdominal infections, especially sepsis. Loading efficiency depended on the proportion of chitosan (CH) and sodium deoxycholate (SDC). The average globule size was 225 to 325 nm. Animal survival improved when the prototype formulation was administered to LPS-induced septic mice. At 4 microg/ml, reduction in TNF-alpha and NO production were observed (P < 0.05) but at lower concentration these changes were not significant (P > 0.05) as compared to positive control (LPS-1 microg/ml). This indicates that chitosan can modify LPS interaction with macrophages, and that formulations have potential to control inflammation associated with sepsis.
载有环丙沙星（CFn）的脂乳剂被开发用于治疗腹腔内感染，尤其是败血症。载药效率取决于壳聚糖（CH）和脱氧胆酸钠（SDC）的比例。平均液滴大小为 225 至 325nm。当将原型制剂施用于脂多糖诱导的败血症小鼠时，动物存活率得到提高。在 4μg/ml 时，观察到 TNF-α和 NO 产生减少（P <0.05），但与阳性对照（LPS-1μg/ml）相比，在较低浓度时这些变化并不显著（P>0.05）。这表明壳聚糖可以修饰 LPS 与巨噬细胞的相互作用，并且这些制剂具有控制与败血症相关的炎症的潜力。
