Pharmaceutics Division, Central Drug Research Institute (CSIR), M. G. Marg, Lucknow 226001, India.
J Biomed Nanotechnol. 2011 Feb;7(1):118-20. doi: 10.1166/jbn.2011.1230.
Amphotericin B (AmB)-loaded poly(lactic-co-glycolic acid, PLGA) nanoparticles (NP) were prepared by solvent displacement. NP of size 160.7 +/- 10.45 nm, with a polydispersity index of 0.093 +/- 0.012 and a zeta-potential of -15.5 +/- 7.2 mV had satisfactory drug entrapment efficiency (42.5 +/- 6.41%). Biphasic drug release characterized by an initial burst followed by subsequent sustained release was observed. Applicability against visceral leishmaniasis and cancer is under investigation.
两性霉素 B（AmB）负载的聚乳酸-共-羟基乙酸（PLGA）纳米粒（NP）通过溶剂置换法制备。所得 NP 的粒径为 160.7 ± 10.45nm，多分散指数为 0.093 ± 0.012，ζ 电位为-15.5 ± 7.2mV，具有令人满意的药物包封效率（42.5 ± 6.41%）。观察到具有初始突释随后持续释放特征的两相药物释放。其对内脏利什曼病和癌症的适用性正在研究中。
