Department of Preventive and Public Health Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
J Periodontol. 2011 Dec;82(12):1685-92. doi: 10.1902/jop.2011.110035. Epub 2011 Apr 12.
The aim of this study is to confirm the association among oral health behaviors, periodontitis, and preeclampsia in Korean women.
This study is designed as a case-control study. Sixteen women with preeclampsia and 48 without preeclampsia post-delivery were included in this study from November 2007 to January 2010. Information was collected on demographics, health behaviors, and obstetric and systemic diseases that may influence the periodontal condition and preeclampsia. Full-mouth periodontal probing was conducted by one trained examiner (KHB). Localized periodontitis was defined as periodontal clinical attachment loss (AL) ≥ 3.5 mm on two or three sites not on the same tooth. In addition, generalized periodontitis was defined as clinical AL ≥ 3.5 mm on ≥ 4 sites not on the same tooth. Gingival crevicular fluid was collected using a sterilized paper point for quantitative analysis of Treponema denticola, Porphyromonas gingivalis, Prevotella intermedia (Pi), and Tannerella forsythia (previously T. forsythensis).
After adjusting for confounders, the adjusted odds ratio (OR) was 4.79 (95% confidence interval [CI]: 1.02 to 29.72) for localized periodontitis and 6.60 (95% CI: 1.25 to 41.61) for generalized periodontitis. In addition, the proportion of floss or interdental brush users in women with preeclampsia was lower than that in women without (adjusted OR: 0.21; 95% CI: 0.02 to 0.93). Pi was significantly more prevalent in women with preeclampsia (P = 0.028).
These results indicate that preeclampsia could be associated with the maternal periodontal condition and interdental cleaning.
本研究旨在确认韩国女性的口腔健康行为、牙周炎与子痫前期之间的关联。
本研究设计为病例对照研究。2007 年 11 月至 2010 年 1 月，共纳入 16 例子痫前期患者和 48 例产后无子痫前期患者。收集人口统计学、健康行为以及可能影响牙周状况和子痫前期的产科和系统性疾病的信息。由一名经过培训的检查者（KHB）进行全口牙周探诊。局部牙周炎定义为两颗或三颗非同一牙齿上的牙周临床附着丧失（AL）≥3.5mm。此外，广义牙周炎定义为≥4 颗非同一牙齿上的牙周临床附着丧失（AL）≥3.5mm。使用无菌纸尖采集龈沟液，用于定量分析牙龈卟啉单胞菌、中间普氏菌（Pi）和福赛坦纳氏菌（以前称为福赛坦纳氏菌）。
调整混杂因素后，局部牙周炎的调整后比值比（OR）为 4.79（95%置信区间[CI]：1.02 至 29.72），广义牙周炎的调整后 OR 为 6.60（95% CI：1.25 至 41.61）。此外，子痫前期妇女使用牙线或牙间刷的比例低于无子痫前期妇女（调整后 OR：0.21；95% CI：0.02 至 0.93）。子痫前期妇女中 Pi 的患病率明显更高（P=0.028）。
这些结果表明，子痫前期可能与产妇牙周状况和牙间清洁有关。
