de Keyser J, De Backer J P, Vauquelin G, Ebinger G
Department of Neurology, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
Brain Res. 1990 Oct 1;528(2):308-10. doi: 10.1016/0006-8993(90)91672-4.
Dopaminergic pathways to the cerebral cortex may be involved in cognitive function. We examined the effect of aging on the D1 dopamine receptors, and their high-agonist affinity (RH) sites, in postmortem human frontal cortex (n = 32; age range, 19-88 years). With aging, there was a significant decrease in the densities of the D1 dopamine receptors, and their RH sites, in human frontal cortex. The age-related reduction of cortical dopaminergic neurotransmission might contribute to the decline in cognitive abilities of elderly persons.
通往大脑皮层的多巴胺能通路可能参与认知功能。我们研究了衰老对死后人类额叶皮质（n = 32；年龄范围19 - 88岁）中D1多巴胺受体及其高激动剂亲和力（RH）位点的影响。随着衰老，人类额叶皮质中D1多巴胺受体及其RH位点的密度显著降低。与年龄相关的皮质多巴胺能神经传递减少可能导致老年人认知能力下降。
