调节性 T 细胞和 Foxp3。
Regulatory T cells and Foxp3.
机构信息
Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Immunol Rev. 2011 May;241(1):260-8. doi: 10.1111/j.1600-065X.2011.01018.x.
Abstract
Regulatory T (Treg) cells play central role in regulation of immune responses to self-antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells. Paucity of Treg cells due to loss-of-function mutations of the Foxp3 gene is responsible for highly aggressive, fatal, systemic immune-mediated inflammatory lesions in mice and humans. Recent studies of Foxp3 expression and function provided critical novel insights into biology of Treg cells and into cellular mechanisms of the immune homeostasis.
摘要
调节性 T（Treg）细胞在调节对自身抗原、过敏原和共生微生物群以及对感染因子和肿瘤的免疫反应方面发挥核心作用。转录因子 Foxp3 是 Treg 细胞的谱系特异性因子。由于 Foxp3 基因突变导致 Treg 细胞数量减少，导致小鼠和人类出现高度侵袭性、致命性、全身性免疫介导的炎症病变。最近对 Foxp3 表达和功能的研究为 Treg 细胞的生物学和免疫稳态的细胞机制提供了重要的新见解。
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Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.重编程的 foxp3(+) 调节性 T 细胞为支持在幼稚小鼠中交叉呈递和 CD8(+) T 细胞启动提供了必要的帮助。
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Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells.转录因子 e2-2 的持续表达维持了成熟浆细胞样树突状细胞的细胞命运。
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A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota.调节性 T 细胞介导的炎症控制对于无共生微生物群落存在的至关重要性。
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