Li Xudong, Zheng Ye
Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010N. Torrey Pines Road, La Jolla, CA 92037, USA.
Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010N. Torrey Pines Road, La Jolla, CA 92037, USA.
Trends Immunol. 2015 Jun;36(6):344-53. doi: 10.1016/j.it.2015.04.006. Epub 2015 May 13.
T regulatory (Treg) cells are central to the maintenance of immune homeostasis. The transcription factor forkhead box P3 (Foxp3) is essential for specifying the Treg cell lineage during development, and continued expression of Foxp3 in mature Treg cells is necessary for suppressive function. Loss of Foxp3 expression in Treg cells is associated with autoimmune pathology. Here, we review recent insights into the mechanisms that maintain Treg cell stability and function, and place these findings within the broader understanding of mechanisms that establish Treg cell identity during development. We integrate emerging principles in Treg cell lineage maintenance with the mechanisms that allow Treg cells to sense and respond to varied inflammatory environments, and outline important areas of future inquiry in this context.
调节性T（Treg）细胞对于维持免疫稳态至关重要。转录因子叉头框P3（Foxp3）在发育过程中对于确定Treg细胞谱系必不可少，并且成熟Treg细胞中Foxp3的持续表达对于抑制功能是必需的。Treg细胞中Foxp3表达的丧失与自身免疫性病理相关。在此，我们综述了关于维持Treg细胞稳定性和功能机制的最新见解，并将这些发现置于对发育过程中建立Treg细胞身份机制的更广泛理解之中。我们将Treg细胞谱系维持中的新兴原理与使Treg细胞感知并响应各种炎症环境的机制相结合，并概述了在此背景下未来研究的重要领域。
