Bacharach-Buhles M, Weindorf N, Altmeyer P
Dermatologische Klinik, Ruhr-Universität Bochum.
Hautarzt. 1990 Nov;41(11):633-5.
This case report deals with the giant form of porokeratosis of Mibelli, porokeratosis Mibelli gigantea. Over the last 40 years, the 55-year-old man concerned had observed a centrifugal expansion of a single hyperkeratotic lesion until it covered the whole of the right hand and forearm. Besides the characteristic histological alterations, we saw capillaries with unusually thickened walls owing to basal lamina multiplication. In the centre of the lesion atrophy of the epidermis and of the corium was visible. These observations indicate an alteration in two germ layers in porokeratosis.
本病例报告涉及米贝利型汗孔角化症的巨大型，即巨大型米贝利汗孔角化症。在过去40年里，这位55岁的男性观察到单个角化过度性损害呈离心性扩大，直至覆盖整个右手和前臂。除了特征性的组织学改变外，我们还看到由于基底膜增生导致管壁异常增厚的毛细血管。在损害中央可见表皮和真皮萎缩。这些观察结果表明汗孔角化症存在两个胚层的改变。
