注意缺陷多动障碍患者扣带回、额叶和顶叶皮质功能障碍。
Cingulate, frontal, and parietal cortical dysfunction in attention-deficit/hyperactivity disorder.
机构信息
Psychiatric Neuroscience Program, MGH–East, CNY2614, Building 149, Thirteenth Street, Charlestown, Massachusetts 02129, USA.
出版信息
Biol Psychiatry. 2011 Jun 15;69(12):1160-7. doi: 10.1016/j.biopsych.2011.01.022. Epub 2011 Apr 13.
Abstract
Functional and structural neuroimaging have identified abnormalities of the brain that are likely to contribute to the neuropathophysiology of attention-deficit/hyperactivity disorder (ADHD). In particular, hypofunction of the brain regions comprising the cingulo-frontal-parietal cognitive-attention network have been consistently observed across studies. These are major components of neural systems that are relevant to ADHD, including cognitive/attention networks, motor systems, and reward/feedback-based processing systems. Moreover, these areas interact with other brain circuits that have been implicated in ADHD, such as the "default mode" resting state network. The ADHD imaging data related to cingulo-frontal-parietal network dysfunction will be selectively highlighted here to help facilitate its integration with the other information presented in this special issue. Together, these reviews will help shed light on the neurobiology of ADHD.
摘要
功能和结构神经影像学已经确定了大脑的异常，这些异常可能有助于注意力缺陷/多动障碍（ADHD）的神经病理生理学。特别是，在跨研究中一致观察到包括扣带-额顶叶认知注意力网络在内的大脑区域的功能低下。这些是与 ADHD 相关的神经系统的主要组成部分，包括认知/注意力网络、运动系统和基于奖励/反馈的处理系统。此外，这些区域与其他与 ADHD 相关的大脑回路相互作用，例如“默认模式”静息状态网络。这里将选择性地突出与扣带-额顶叶网络功能障碍相关的 ADHD 成像数据，以帮助促进其与本期特刊中呈现的其他信息的整合。这些综述将有助于揭示 ADHD 的神经生物学。
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