未经治疗的 ADHD 成年患者前扣带回体积的改变：一项初步研究。
Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study.
机构信息
Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
出版信息
J Atten Disord. 2010 Jan;13(4):407-13. doi: 10.1177/1087054709351671.
Abstract
OBJECTIVE
We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD.
METHOD
Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naïve adults with ADHD (n = 13).
RESULTS
There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group.
CONCLUSION
These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment.
摘要
目的
我们旨在探讨未经治疗的 ADHD 成人前扣带皮层（ACC）脑改变的初步结果。ACC 是认知控制和注意力、情感和驱动力分配的核心脑节点。因此，其解剖结构的改变可能导致冲动、多动和注意力不集中，这些都是 ADHD 的主要行为表现。
方法
对对照组（n=22）、治疗组（n=13）和未经治疗的 ADHD 成人组（n=13）进行 ACC 分割和分区。
结果
未经治疗组的左 ACC 体积比对照组减少了 21%。此外，治疗组的右 ACC 体积比对照组减少了 23%。
结论
这些结果表明，在 ADHD 中，存在持续到成年的体积缺陷，与药物治疗无关。
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