Orthopedic Surgery Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Injury. 2011 Jun;42(6):609-13. doi: 10.1016/j.injury.2011.03.029. Epub 2011 Apr 13.
Over the last decades, the medical world has advanced dramatically in the understanding of fracture repair. The three components needed for fracture healing are osteoconduction, osteoinduction and osteogenesis. With newly designed scaffolds, ex vivo produced growth factors and isolated stem cells, most of the challenges of critical size bone defects have been resolved in vitro, and in some cases in animal models as well. However, there are still challenges needed to be overcome before these technologies can be fully converted from the bench to the bedside. These technological and biological advancements need to be converted to mass production of affordable products that can be used in every part of the world. Vascularity, full substation of scaffolds by native bone, and bio-safety are the three most critical steps to be challenged before reaching the clinical setting.
在过去的几十年中，医学领域在骨折修复方面取得了显著的进展。骨折愈合需要的三个要素是骨传导、骨诱导和骨生成。通过新型设计的支架、体外产生的生长因子和分离的干细胞，大多数临界尺寸骨缺损的挑战已经在体外得到解决，在某些情况下，在动物模型中也得到了解决。然而，在这些技术能够从实验室完全转化为临床应用之前，仍需要克服一些挑战。这些技术和生物方面的进步需要转化为大规模生产的负担得起的产品，以便在全球范围内使用。血管化、支架完全被原生骨取代以及生物安全性是在达到临床应用之前需要面临的三个最关键的挑战。
