视神经脊髓炎和多发性硬化患者记忆性 Th17 细胞增加。
Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis.
机构信息
MS Clinical Research Center, Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
出版信息
J Neuroimmunol. 2011 May;234(1-2):155-60. doi: 10.1016/j.jneuroim.2011.03.009. Epub 2011 Apr 12.
OBJECT
To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS).
PATIENTS AND METHODS
The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits.
RESULTS
Memory Th17 proportion and IL-17A level were much higher in patients with NMO or MS and were related to clinical features. After high-dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A and IL-23 levels were decreased.
CONCLUSIONS
Memory Th17 is related to the development and relapse of NMO and MS, and IVMP can inhibit memory Th17.
目的
研究记忆性 Th17 细胞在视神经脊髓炎（NMO）或多发性硬化（MS）患者中的临床相关性。
方法
通过流式细胞术测定外周血记忆性 Th17 细胞的比例。采用 ELISA 试剂盒检测血清 IL-17A 和 IL-23 水平。
结果
NMO 或 MS 患者的记忆性 Th17 比例和 IL-17A 水平均明显升高，并与临床特征相关。大剂量静脉注射甲基泼尼松龙（IVMP）治疗后，记忆性 Th17 比例以及 IL-17A 和 IL-23 水平降低。
结论
记忆性 Th17 与 NMO 和 MS 的发生和复发有关，IVMP 可抑制记忆性 Th17。
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