Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
J Neuroimmunol. 2013 Aug 15;261(1-2):87-91. doi: 10.1016/j.jneuroim.2013.04.021. Epub 2013 May 28.
Interleukin (IL)-22 secreting CD4(+) T (Th22) cells and IL-22 are involved in the pathogenesis of autoimmune disease, but their role in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unclear. We measured the proportion of Th22, Th17, CD4(+)IL-22(+)IL-17A(+) T cells and serum IL-22 in NMO and MS patients. The proportion of Th22 cells, Th17 cells and serum IL-22 were increased in patients with NMO and MS. Our findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS.
白细胞介素 (IL)-22 分泌的 CD4(+)T（Th22）细胞和 IL-22 参与自身免疫性疾病的发病机制，但它们在视神经脊髓炎 (NMO) 和多发性硬化症 (MS) 中的作用尚不清楚。我们测量了 NMO 和 MS 患者 Th22、Th17、CD4(+)IL-22(+)IL-17A(+)T 细胞和血清 IL-22 的比例。NMO 和 MS 患者的 Th22 细胞、Th17 细胞和血清 IL-22 比例增加。我们的研究结果表明，Th22 细胞的增加可能在 NMO 和 MS 的发病机制中起重要作用。
