Department of Epidemiology, School of Public Health, University of Indonesia, Depok, West Java, Indonesia.
Asia Pac J Public Health. 2011 May;23(3):369-77. doi: 10.1177/1010539511403605. Epub 2011 Apr 13.
Risk of aplastic anemia (AA) from occupational exposures to pesticides and industrial chemicals was evaluated in a hospital-based case control study in Thailand (541 cases of AA and 2261 controls). Exposure data were obtained via participants' self-reports and by experts' assessments and the data from these 2 exposure assessment methods were compared. There was an increased risk of AA associated with several classes of pesticides measured by either self-report or expert assessment. The strongest associations were seen in those whose exposures were identified both by self-report and by expert assessment. Comparing very high/high to no exposure, odds ratios (95% confidence intervals) were as follows: for organophosphates 3.20 (1.87-5.46), carbamates 4.75 (1.92-11.75), organochlorines 6.04 (1.31-27.84), and paraquat 2.17 (1.11-4.25). There were correlations among the pesticides because many types were used in the same job, so it was not possible to determine whether these risks were independent or because of confounding of one by another.
在泰国进行的一项基于医院的病例对照研究中，评估了职业暴露于农药和工业化学品导致再生障碍性贫血（AA）的风险（541 例 AA 患者和 2261 例对照）。通过参与者的自我报告和专家评估获得暴露数据，并比较了这两种暴露评估方法的数据。通过自我报告或专家评估测量的几类农药与 AA 风险增加相关。在那些自我报告和专家评估都确定暴露的人中，观察到最强的关联。将极高/高暴露与无暴露进行比较，优势比（95%置信区间）如下：有机磷 3.20（1.87-5.46），氨基甲酸酯 4.75（1.92-11.75），有机氯 6.04（1.31-27.84），百草枯 2.17（1.11-4.25）。由于许多类型的农药在同一种工作中使用，因此存在农药之间的相关性，因此无法确定这些风险是相互独立的，还是由于另一种风险的混杂所致。
