Fleming L E, Timmeny W
Department of Epidemiology and Public Health, University of Miami School of Medicine, FL 33101.
J Occup Med. 1993 Nov;35(11):1106-16. doi: 10.1097/00043764-199311000-00013.
The majority of cases of aplastic anemia, a rare previously lethal disease, are of unknown etiology. Nevertheless, for the past 3 decades, case reports and case series of aplastic anemia have suggested an etiologic association between aplastic anemia and pesticide exposure. A review of the medical literature, including basic science literature, confirms a possible etiologic association between pesticide exposure and aplastic anemia. Two hundred and eighty cases of aplastic anemia associated with pesticide exposure were reported in the literature. The majority of these cases were young (mean age, 34 years; median, 28), with a short latency (mean, 5 months) and with a history of occupational exposure to pesticides. The pesticide exposures reported were the organochlorines and organophosphates, both commonly used pesticides throughout the world. Therapeutic and methodologic issues as well as future directions for research into this etiologic association are discussed.
再生障碍性贫血是一种曾被认为罕见且致命的疾病，大多数病例病因不明。然而，在过去30年里，再生障碍性贫血的病例报告和病例系列研究表明，再生障碍性贫血与接触农药之间存在病因学关联。对包括基础科学文献在内的医学文献进行回顾，证实了接触农药与再生障碍性贫血之间可能存在病因学关联。文献报道了280例与接触农药相关的再生障碍性贫血病例。这些病例大多数为年轻人（平均年龄34岁；中位数28岁），潜伏期短（平均5个月），且有职业接触农药史。报告的农药接触类型为有机氯和有机磷，这两种都是全球常用的农药。本文还讨论了治疗和方法学问题以及针对这种病因学关联的未来研究方向。
