Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA.
Adv Anat Pathol. 2011 May;18(3):179-89. doi: 10.1097/PAP.0b013e318216980c.
Malignant biphasic tumors of the lungs are rare primary tumors of the bronchopulmonary system. These tumors are composed of malignant epithelial and mesenchymal elements and together comprise <2% of all primary pulmonary neoplasms. The tumors belonging to this group include pulmonary blastoma, pleuropulmonary blastoma, and carcinosarcoma. In this study, the clinicopathologic features, immunohistochemical phenotype, molecular biological characteristics, and the differential diagnosis of these uncommon neoplasms are discussed.
肺部的恶性双相性肿瘤是肺部支气管系统罕见的原发性肿瘤。这些肿瘤由恶性上皮和间叶成分组成，占所有原发性肺肿瘤的<2%。属于该组的肿瘤包括肺胚细胞瘤、胸膜肺胚细胞瘤和癌肉瘤。本研究讨论了这些罕见肿瘤的临床病理特征、免疫组织化学表型、分子生物学特征和鉴别诊断。
