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1
The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype.在二次免疫应答中帮助B细胞的MRC OX - 22 - CD4 + T细胞源自具有MRC OX - 22 + CD4 + 表型的初始前体细胞。
J Exp Med. 1989 Mar 1;169(3):653-62. doi: 10.1084/jem.169.3.653.
2
Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies.抗CD2单克隆抗体对大鼠T淋巴细胞的激活作用。
J Exp Med. 1988 Jun 1;167(6):1861-72. doi: 10.1084/jem.167.6.1861.
3
T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation.在有丝分裂原或同种异体刺激下，辅助B细胞对可溶性抗原作出反应的T细胞与产生白细胞介素2的T细胞是有区别的。
J Exp Med. 1986 Apr 1;163(4):774-86. doi: 10.1084/jem.163.4.774.
4
Subsets of thymopoietic rat thymocytes defined by expression of the CD2 antigen and the MRC OX-22 determinant of the leukocyte-common antigen CD45.通过CD2抗原表达以及白细胞共同抗原CD45的MRC OX - 22决定簇所定义的大鼠胸腺生成胸腺细胞亚群。
Eur J Immunol. 1989 Dec;19(12):2289-95. doi: 10.1002/eji.1830191217.
5
Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts.活化大鼠T淋巴细胞的抗原，包括仅在CD4阳性T母细胞上检测到的一种50,000道尔顿的分子。
Mol Immunol. 1987 Dec;24(12):1281-90. doi: 10.1016/0161-5890(87)90122-2.
6
MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen.MRC OX-22，一种单克隆抗体，可标记T淋巴细胞的一个新亚群，并与白细胞共同抗原的高分子量形式发生反应。
J Exp Med. 1983 Sep 1;158(3):795-810. doi: 10.1084/jem.158.3.795.
7
The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes.MRC OX - 44抗原标记了大鼠胸腺细胞中一个功能相关的亚群。
J Exp Med. 1987 Jan 1;165(1):1-13. doi: 10.1084/jem.165.1.1.
8
Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes.来自胸腺细胞、T淋巴细胞和B淋巴细胞的大鼠白细胞共同抗原的分子和抗原异质性。
Eur J Immunol. 1985 Feb;15(2):168-73. doi: 10.1002/eji.1830150211.
9
Interactions between T helper cells and dendritic cells during the rat mixed lymphocyte reaction.大鼠混合淋巴细胞反应中辅助性T细胞与树突状细胞之间的相互作用。
J Exp Med. 1985 Nov 1;162(5):1546-60. doi: 10.1084/jem.162.5.1546.
10
MRC OX-19: a monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses.MRC OX-19：一种标记大鼠T淋巴细胞并增强体外增殖反应的单克隆抗体。
Eur J Immunol. 1984 Mar;14(3):260-7. doi: 10.1002/eji.1830140311.

引用本文的文献

1
Influence of PMN leukocyte-mediated pancreatic damage on the systemic immune response in severe acute pancreatitis in rats.中性粒细胞介导的胰腺损伤对大鼠重症急性胰腺炎全身免疫反应的影响。
Dig Dis Sci. 2004 Aug;49(7-8):1348-57. doi: 10.1023/b:ddas.0000037833.16433.77.
2
Qualitative differences between naïve and memory T cells.初始T细胞与记忆T细胞之间的质性差异。
Immunology. 2002 Jun;106(2):127-38. doi: 10.1046/j.1365-2567.2002.01447.x.
3
Lymphocyte trafficking: CD4 T cells with a 'memory' phenotype (CD45RC-) freely cross lymph node high endothelial venules in vivo.淋巴细胞迁移：具有“记忆”表型（CD45RC-）的CD4 T细胞在体内可自由穿过淋巴结高内皮微静脉。
Immunology. 1998 Apr;93(4):447-54. doi: 10.1046/j.1365-2567.1998.00471.x.
4
Identical expression of CD45R isoforms by CD45RC+ 'revertant' memory and CD45RC+ naive CD4 T cells.CD45RC +“回复性”记忆性CD4 T细胞和CD45RC +初始CD4 T细胞对CD45R亚型的表达相同。
Immunology. 1997 Jul;91(3):323-30. doi: 10.1046/j.1365-2567.1997.00267.x.
5
CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen.CD45RC 异构体定义了两种 CD4 记忆性 T 细胞，其中一种依赖于持续存在的抗原。
J Exp Med. 1997 Feb 17;185(4):767-76. doi: 10.1084/jem.185.4.767.
6
In vivo lymphokine production in experimental autoimmune uveoretinitis.实验性自身免疫性葡萄膜视网膜炎中的体内淋巴因子产生
Immunology. 1993 Mar;78(3):387-92.
7
Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.正常大鼠的T细胞库中存在具有引发糖尿病潜能的细胞的证据。抑制这种自身免疫潜能的CD4 + T细胞亚群的特征。
J Exp Med. 1993 Mar 1;177(3):627-36. doi: 10.1084/jem.177.3.627.
8
Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages.肺泡巨噬细胞对肺组织中T细胞功能的调节
Immunology. 1993 Oct;80(2):266-72.
9
Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation.CD45异构体表达的变化伴随着抗原诱导的小鼠T细胞活化。
Proc Natl Acad Sci U S A. 1989 Sep;86(17):6734-8. doi: 10.1073/pnas.86.17.6734.
10
Age-related factors in cyclosporine-induced syngeneic graft-versus-host disease: regulatory role of marrow-derived T lymphocytes.环孢素诱导的同基因移植物抗宿主病中的年龄相关因素：骨髓来源T淋巴细胞的调节作用
J Exp Med. 1990 Jul 1;172(1):85-94. doi: 10.1084/jem.172.1.85.

本文引用的文献

1
THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT.大鼠淋巴细胞的再循环途径
Proc R Soc Lond B Biol Sci. 1964 Jan 14;159:257-82. doi: 10.1098/rspb.1964.0001.
2
Purification of human C3b inactivator by monoclonal-antibody affinity chromatography.用单克隆抗体亲和层析法纯化人C3b灭活剂。
Biochem J. 1982 Apr 1;203(1):293-8. doi: 10.1042/bj2030293.
3
A repopulation assay for B and T lymphocyte stem cells employing radiation chimaeras.一种利用辐射嵌合体对B和T淋巴细胞干细胞进行再增殖检测的方法。
Cell Tissue Kinet. 1981 Jul;14(4):445-64. doi: 10.1111/j.1365-2184.1981.tb00551.x.
4
The autologous mixed-lymphocyte reaction.自体混合淋巴细胞反应
Adv Immunol. 1981;31:271-312. doi: 10.1016/s0065-2776(08)60923-2.
5
Functions of rat T-lymphocyte subsets isolated by means of monoclonal antibodies.用单克隆抗体分离的大鼠T淋巴细胞亚群的功能。
Immunol Rev. 1983;74:57-82. doi: 10.1111/j.1600-065x.1983.tb01084.x.
6
MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen.MRC OX-22，一种单克隆抗体，可标记T淋巴细胞的一个新亚群，并与白细胞共同抗原的高分子量形式发生反应。
J Exp Med. 1983 Sep 1;158(3):795-810. doi: 10.1084/jem.158.3.795.
7
The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.单次注射成熟T细胞后，无胸腺裸鼠体内功能性T淋巴细胞的稳定且持久的扩增。
J Immunol. 1987 Sep 1;139(5):1379-84.
8
The isolation and characterization of the human suppressor inducer T cell subset.人类抑制诱导性T细胞亚群的分离与鉴定
J Immunol. 1985 Mar;134(3):1508-15.
9
Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets.人类天然和记忆性T细胞：辅助诱导和抑制诱导亚群的重新诠释
Immunol Today. 1988 Jul-Aug;9(7-8):195-9. doi: 10.1016/0167-5699(88)91212-1.
10
The autonomy of CD8+ T cells in vitro and in vivo.CD8 + T细胞在体外和体内的自主性。
Immunology. 1988 Oct;65(2):249-57.

在二次免疫应答中帮助B细胞的MRC OX - 22 - CD4 + T细胞源自具有MRC OX - 22 + CD4 + 表型的初始前体细胞。

The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype.

作者信息

Powrie F, Mason D

机构信息

MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford, UK.

出版信息

J Exp Med. 1989 Mar 1;169(3):653-62. doi: 10.1084/jem.169.3.653.

DOI:10.1084/jem.169.3.653
PMID:2784479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189268/
Abstract

CD4+ T cells in the rat can be divided into two nonoverlapping subsets by their reactivity with the mAb MRC OX-22, which binds some of the high molecular weight forms of the CD45 antigen. The lineage relationship between subsets of CD4+ T cells expression different forms of CD45 has been a controversial issue for some time. Experiments described in this paper address this question using in vivo assays of T cell reactivity. Analysis of primary antibody responses in vivo show that it is MRC OX-22+ CD4+ T cells that are active in these assays, whereas antigen-primed T cells that provide helper activity for secondary antibody responses in vivo have the MRC OX-22- CD4+ phenotype. It is demonstrated that these memory T cells derive from MRC OX-22+ CD4+ T cell precursors and not from a putative separate lineage. It is concluded that with respect to the provision of help for B cells, MRC OX-22+ CD4+ T cells are precursors of memory cells with the phenotype MRC OX-22- CD4+.

摘要

大鼠中的CD4+ T细胞可根据其与单克隆抗体MRC OX-22的反应性分为两个不重叠的亚群，该抗体可结合某些高分子量形式的CD45抗原。一段时间以来，表达不同形式CD45的CD4+ T细胞亚群之间的谱系关系一直是一个有争议的问题。本文所述的实验使用T细胞反应性的体内测定法来解决这个问题。体内初次抗体反应分析表明，在这些测定中活跃的是MRC OX-22+ CD4+ T细胞，而在体内为二次抗体反应提供辅助活性的抗原致敏T细胞具有MRC OX-22- CD4+表型。结果表明，这些记忆T细胞来源于MRC OX-22+ CD4+ T细胞前体，而非假定的独立谱系。结论是，就为B细胞提供辅助而言，MRC OX-22+ CD4+ T细胞是具有MRC OX-22- CD4+表型的记忆细胞的前体。