撤回:针对严重精神障碍患者的积极社区治疗。
WITHDRAWN: Assertive community treatment for people with severe mental disorders.
作者信息
Marshall Max, Lockwood Austin
机构信息
University of Manchester, The Lantern Centre, Vicarage Lane, Of Watling Street Road, Fulwood, Preston., Lancashire, UK.
出版信息
Cochrane Database Syst Rev. 2011 Apr 13;2011(4):CD001089. doi: 10.1002/14651858.CD001089.pub2.
BACKGROUND
Assertive Community Treatment (ACT) was developed in the early 1970s as a response to the closing down of psychiatric hospitals. ACT is a team-based approach aiming at keeping ill people in contact with services, reducing hospital admissions and improving outcome, especially social functioning and quality of life.
OBJECTIVES
To determine the effectiveness of Assertive Community Treatment (ACT) as an alternative to i. standard community care, ii. traditional hospital-based rehabilitation, and iii. case management. For each of the three comparisons the main outcome indices were i. remaining in contact with the psychiatric services, ii. extent of psychiatric hospital admissions, iii. clinical and social outcome and iv. costs.
SEARCH STRATEGY
Electronic searches of CINAHL (1982-1997), the Cochrane Schizophrenia Group's Register of trials (1997), EMBASE (1980-1997), MEDLINE (1966-1997), PsycLIT (1974-1997) and SCISEARCH (1997) were undertaken. References of all identified studies were searched for further trial citations.
SELECTION CRITERIA
The inclusion criteria were that studies should i. be randomised controlled trials, ii. have compared ACT to standard community care, hospital-based rehabilitation, or case management and iii. have been carried out on people with severe mental disorder the majority of whom were aged from 18 to 65. Studies of ACT were defined as those in which the investigators described the intervention as "Assertive Community Treatment" or one of its synonyms. Studies of ACT as an alternative to hospital admission, hospital diversion programmes, for those in crisis, were excluded. The reliability of the inclusion criteria were evaluated.
DATA COLLECTION AND ANALYSIS
Three types of outcome data were available: i. categorical data, ii. numerical data based on counts of real life events (count data) and iii. numerical data collected by standardised instruments (scale data). Categorical data were extracted twice and then cross-checked. Peto Odds Ratios and the number needed to treat (NNT) were calculated. Numerical count data were extracted twice and cross-checked. Count data could not be combined across studies for technical reasons (the data were skewed) but all relevant observations based on count data were reported in the review. Numerical scale data were subject to a quality assessment. The validity of the quality assessment was itself assessed. Numerical scale data of suitable quality were combined using the standardised mean difference statistic where possible, otherwise the data were reported in the text or 'Other data tables' of the review.
MAIN RESULTS
ACT versus standard community care Those receiving ACT were more likely to remain in contact with services than people receiving standard community care (OR 0.51, 99%CI 0.37-0.70). People allocated to ACT were less likely to be admitted to hospital than those receiving standard community care (OR 0.59, 99%CI 0.41-0.85) and spent less time in hospital. In terms of clinical and social outcome, significant and robust differences between ACT and standard community care were found on i. accommodation status, ii. employment and iii. patient satisfaction. There were no differences between ACT and control treatments on mental state or social functioning. ACT invariably reduced the cost of hospital care, but did not have a clear cut advantage over standard care when other costs were taken into account.ACT versus hospital-based rehabilitation services Those receiving ACT were no more likely to remain in contact with services than those receiving hospital-based rehabilitation, but confidence intervals for the odds ratio were wide. People getting ACT were significantly less likely to be admitted to hospital than those receiving hospital-based rehabilitation (OR 0.2, 99%CI 0.09-0.46) and spent less time in hospital. Those allocated to ACT were significantly more likely to be living independently (OR (for not living independently) 0.19, 99%CI 0.06-0.54), but there were no other significant and robust differences in clinical or social outcome. There was insufficient data on costs to permit comparison.ACT versus case management There were no data on numbers remaining in contact with the psychiatric services or on numbers admitted to hospital. People allocated to ACT consistently spent fewer days in hospital than those given case management. There was insufficient data to permit robust comparisons of clinical or social outcome. The cost of hospital care was consistently less for those allocated to ACT, but ACT did not have a clear cut advantage over case management when other costs were taken into account.
AUTHORS' CONCLUSIONS: ACT is a clinically effective approach to managing the care of severely mentally ill people in the community. ACT, if correctly targeted on high users of in-patient care, can substantially reduce the costs of hospital care whilst improving outcome and patient satisfaction. Policy makers, clinicians, and consumers should support the setting up of ACT teams.
背景
积极社区治疗(ACT)于20世纪70年代初开发,作为对精神病医院关闭的回应。ACT是一种基于团队的方法,旨在使患者持续接受服务,减少住院次数并改善治疗效果,特别是社会功能和生活质量。
目的
确定积极社区治疗(ACT)作为以下替代方案的有效性:i. 标准社区护理;ii. 传统的基于医院的康复治疗;iii. 病例管理。对于这三项比较中的每一项,主要结局指标为:i. 持续接受精神科服务;ii. 精神病医院住院程度;iii. 临床和社会结局;iv. 成本。
检索策略
对CINAHL(1982 - 1997)、Cochrane精神分裂症研究组试验注册库(1997)、EMBASE(1980 - 1997)、MEDLINE(1966 - 1997)、PsycLIT(1974 - 1997)和SCISEARCH(1997)进行了电子检索。对所有已识别研究的参考文献进行检索以获取更多试验引用。
选择标准
纳入标准为研究应:i. 为随机对照试验;ii. 已将ACT与标准社区护理、基于医院的康复治疗或病例管理进行比较;iii. 在大多数年龄为18至65岁的严重精神障碍患者中进行。ACT研究被定义为研究者将干预描述为“积极社区治疗”或其同义词之一的研究。将ACT作为危机中患者住院替代方案、医院分流项目的研究排除。对纳入标准的可靠性进行了评估。
数据收集与分析
有三种类型的结局数据:i. 分类数据;ii. 基于现实生活事件计数的数值数据(计数数据);iii. 通过标准化工具收集的数值数据(量表数据)。分类数据提取两次然后进行交叉核对。计算Peto比值比和需治疗人数(NNT)。数值计数数据提取两次并交叉核对。由于技术原因(数据存在偏态),计数数据无法在各研究间合并,但综述中报告了基于计数数据的所有相关观察结果。数值量表数据进行了质量评估。对质量评估的有效性本身进行了评估。尽可能使用标准化均数差统计量合并质量合适的数值量表数据,否则在综述的正文或“其他数据表”中报告数据。
主要结果
ACT与标准社区护理 接受ACT的患者比接受标准社区护理的患者更有可能持续接受服务(OR 0.51,99%CI 0.37 - 0.70)。分配到ACT的患者比接受标准社区护理的患者住院可能性更小(OR 0.59,99%CI 0.41 - 0.85)且住院时间更短。在临床和社会结局方面,ACT与标准社区护理在以下方面存在显著且稳定的差异:i. 居住状况;ii. 就业;iii. 患者满意度。ACT与对照治疗在精神状态或社会功能方面无差异。ACT始终降低了医院护理成本,但考虑其他成本时,与标准护理相比没有明显优势。ACT与基于医院的康复服务 接受ACT的患者与接受基于医院的康复治疗的患者持续接受服务的可能性没有更高,但比值比的置信区间较宽。接受ACT治疗的患者比接受基于医院的康复治疗的患者住院可能性显著更低(OR 0.2,99%CI 0.09 - 0.46)且住院时间更短。分配到ACT的患者独立生活可能性显著更高(OR(非独立生活)0.19,99%CI 0.06 - 0.54),但在临床或社会结局方面没有其他显著且稳定的差异。关于成本的数据不足,无法进行比较。ACT与病例管理 关于持续接受精神科服务的人数或住院人数没有数据。分配到ACT的患者住院天数始终比接受病例管理治疗的患者少。没有足够的数据对临床或社会结局进行可靠比较。分配到ACT的患者医院护理成本始终更低,但考虑其他成本时,ACT与病例管理相比没有明显优势。
作者结论
ACT是一种在社区管理严重精神疾病患者护理的临床有效方法。如果将ACT正确地针对住院治疗的高使用人群,可在改善治疗效果和患者满意度的同时大幅降低医院护理成本。政策制定者、临床医生和消费者应支持建立ACT团队。
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