Heinke Ramona, Franke Katrin, Porzel Andrea, Wessjohann Ludger A, Ali Nasser A Awadh, Schmidt Jürgen
Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle/Saale, Germany.
Pharmacognosy Department, Faculty of Pharmacy, Sana'a University, P.O. Box 13150, Sana'a, Yemen.
Phytochemistry. 2011 Jun;72(9):929-34. doi: 10.1016/j.phytochem.2011.03.008. Epub 2011 Apr 12.
The linear furanocoumarins 5-(2,3-epoxy-3-methyl-butoxy)-chalepensin, 5-methoxy-3-(3-methyl-2,3-dihydroxybutyl)-psoralen-diacetate (7), 5-methoxy-3-[3-(β-D-glucopyranosyloxy)-2-acetyloxy-3-methyl-butyl]-psoralen and 5-(3-methyl-2,3-dihydroxybutyloxy)-3-[3-(β-D-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-psoralen, and the coumarin derivative 7-hydroxy-5-methoxy-6-carboxymethyl-3-[3-(β-D-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-coumarin were isolated from the leaves of Dorstenia foetida (Moraceae) along with the known compounds psoralen, bergapten, isopimpinellin, phellopterin, 5-methoxychalepensin and turbinatocoumarin. Further furanocoumarins were characterized by ESI-MS/MS investigations. The nonpolar extracts of D. foetida exhibit antifungal, antibacterial and cytotoxic activity, however, no anthelminthic activity.
从桑科植物臭桑（Dorstenia foetida）的叶子中分离出了线性呋喃香豆素5-(2,3-环氧-3-甲基丁氧基)-查莱平、5-甲氧基-3-(3-甲基-2,3-二羟基丁基)-补骨脂素二乙酸酯（7）、5-甲氧基-3-[3-(β-D-吡喃葡萄糖氧基)-2-乙酰氧基-3-甲基丁基]-补骨脂素和5-(3-甲基-2,3-二羟基丁氧基)-3-[3-(β-D-吡喃葡萄糖氧基)-2-羟基-3-甲基丁基]-补骨脂素，以及香豆素衍生物7-羟基-5-甲氧基-6-羧甲基-3-[3-(β-D-吡喃葡萄糖氧基)-2-羟基-3-甲基丁基]-香豆素，同时还分离出了已知化合物补骨脂素、佛手柑内酯、异茴芹素、黄樟素、5-甲氧基查莱平以及陀螺香豆素。通过电喷雾串联质谱（ESI-MS/MS）研究对其他呋喃香豆素进行了表征。臭桑的非极性提取物具有抗真菌、抗菌和细胞毒性活性，然而，没有驱虫活性。
