University Psychiatric Centre Catholic University Leuven, Campus Kortenberg, Kortenberg, Belgium.
Schizophr Res. 2011 Jul;129(2-3):122-7. doi: 10.1016/j.schres.2011.03.018. Epub 2011 Apr 14.
The aim of the present study was to identify if lack of physical activity participation and an impaired functional exercise capacity compared with healthy controls contributed to an impaired health related quality of life (HRQL). We also evaluated whether the presence of metabolic syndrome (MetS) could explain the variability in HRQL in patients.
Patients with DSM-IV schizophrenia (n=60) and age- and gender-matched healthy controls (n=40) completed the SF-36 quality of life scale and the Baecke Physical Activity Questionnaire and performed a 6 minute walk test (6MWT). Patients also received a fasting metabolic laboratory screening. Linear multiple regression analysis was used to assess the associations between demographical and clinical variables and HRQL outcomes.
Physical and mental HRQL and the Baecke and 6MWT-scores were significantly lower in patients with schizophrenia compared with matched healthy controls. When in schizophrenia patients all individual HRQL-predictors were included in a regression model, only BMI and lack of PA during leisure time remained significant predictors for physical HRQL while for mental HRQL no significant predictor remained. The impaired functional exercise capacity and the presence of MetS did not additionally explain the variance in HRQL.
Physical HRQL in patients with schizophrenia is not only related to increased BMI but also to lack of leisure time physical activity. A reduced physical HRQL in patients with MetS appears to be related to their greater BMI, rather than to MetS per se. Present findings provide further support for routinely incorporating physical activity within rehabilitation programs and clinical assessments.
本研究旨在确定与健康对照组相比，缺乏身体活动参与和受损的功能运动能力是否导致健康相关生活质量（HRQL）受损。我们还评估了代谢综合征（MetS）的存在是否可以解释患者 HRQL 的变异性。
60 名 DSM-IV 精神分裂症患者和年龄、性别匹配的 40 名健康对照者完成了 SF-36 生活质量量表和 Baecke 体力活动问卷，并进行了 6 分钟步行测试（6MWT）。患者还接受了空腹代谢实验室筛查。线性多元回归分析用于评估人口统计学和临床变量与 HRQL 结果之间的关联。
与匹配的健康对照组相比，精神分裂症患者的身体和心理 HRQL 以及 Baecke 和 6MWT 评分明显较低。当在精神分裂症患者中纳入所有个体 HRQL 预测因子的回归模型时，仅 BMI 和休闲时间缺乏 PA 仍然是身体 HRQL 的显著预测因子，而对于心理 HRQL，没有显著的预测因子仍然存在。受损的功能运动能力和 MetS 的存在并没有额外解释 HRQL 的变异性。
精神分裂症患者的身体 HRQL 不仅与 BMI 增加有关，还与缺乏休闲时间的体力活动有关。患有 MetS 的患者的身体 HRQL 降低似乎与其更大的 BMI 有关，而不是与 MetS 本身有关。目前的研究结果进一步支持在康复计划和临床评估中常规纳入体力活动。
