Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA.
Dement Geriatr Cogn Disord. 2011;31(4):259-67. doi: 10.1159/000324713. Epub 2011 Apr 13.
Given that high cholesterol levels at midlife are a risk factor for future cognitive decline, the goal of the current study was to determine if cholesterol-related alterations in the cerebrovascular response to cognition could be detected at midlife.
Forty adults, aged 40-60 years, performed a 2-Back working memory task during fMRI. The associations between serum total cholesterol, HDL-cholesterol, and total cholesterol/HDL-cholesterol concentrations to task-related activation intensity were modeled using multivariate multiple regression (two-tailed p < 0.02).
Higher levels of total cholesterol/HDL-cholesterol related to reduced working memory-related activation intensity in the left inferior parietal lobe, right superior frontal gyrus, and right middle frontal gyrus.
These data provide preliminary support for a deleterious effect of elevated total cholesterol/HDL-cholesterol ratio on cerebrovascular support for cognition in midlife.
鉴于中年时胆固醇水平较高是未来认知能力下降的一个风险因素，本研究的目的是确定是否可以在中年时检测到与胆固醇相关的脑血管对认知的反应改变。
40 名年龄在 40-60 岁的成年人在 fMRI 期间执行 2 背工作记忆任务。使用多元多变量回归（双侧 p < 0.02）来模拟血清总胆固醇、高密度脂蛋白胆固醇和总胆固醇/高密度脂蛋白胆固醇浓度与任务相关激活强度之间的关系。
较高的总胆固醇/高密度脂蛋白胆固醇水平与左顶下小叶、右额上回和右中额回的工作记忆相关激活强度降低有关。
这些数据初步支持了较高的总胆固醇/高密度脂蛋白胆固醇比值对中年认知的脑血管支持产生有害影响。
