Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton Campus, Victoria, Australia.
Autophagy. 2011 Jun;7(6):666-8. doi: 10.4161/auto.7.6.15812. Epub 2011 Jun 1.
The proton pumping activity of V-ATPase is responsible for acidification of the lysosome/vacuole. The low lumenal pH of this organelle stimulates the activity of a battery of resident hydrolases responsible for the degradation of various nonselective and selective cargos delivered by autophagic processes. However, the role of V-ATPase in membrane dynamics required for the uptake of autophagic cargo is far from fully understood. Consideration of the available data leads us to speculate that autophagic processes involving direct membrane-to-membrane contacts between the selected cargo and the vacuolar membrane require functional V-ATPase.
V-ATPase 的质子泵活性负责溶酶体/液泡的酸化。该细胞器的低腔内腔 pH 值刺激了一系列驻留水解酶的活性，这些酶负责降解通过自噬过程递送到各种非选择性和选择性货物的降解。然而，V-ATPase 在自噬货物摄取所需的膜动力学中的作用远未完全了解。对现有数据的考虑使我们推测，涉及选定货物与液泡膜之间直接的膜到膜接触的自噬过程需要功能性的 V-ATPase。
