Xie Jin, Huang Shengjie, Huang Haozhou, Deng Xuan, Yue Pengfei, Lin Junzhi, Yang Ming, Han Li, Zhang Ding-Kun
State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
State Key Laboratory of Innovation Medicine and High Efficiency and Energy Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Front Pharmacol. 2021 Apr 21;12:644952. doi: 10.3389/fphar.2021.644952. eCollection 2021.
Psoriasis, an incurable autoimmune skin disease, is one of the most common immune-mediated disorders. Presently, numerous clinical research studies are underway, and treatment options are available. However, these treatments focus on improving symptoms of the disease and fail to achieve a radical cure; they also have certain toxic side effects. In recent years, natural products have increasingly gained attention because of their high efficiency and low toxicity. Despite their obvious therapeutic effects, natural products' biological activity was limited by their instability, poor solubility, and low bioavailability. Novel drug delivery systems, including liposomes, lipospheres, nanostructured lipid carriers, niosomes, nanoemulsions, nanospheres, microneedles, ethosomes, nanocrystals, and foams could potentially overcome the limitations of poor water solubility and permeability in traditional drug delivery systems. Thus, to achieve a therapeutic effect, the drug can reach the epidermis and dermis in psoriatic lesions to interact with the immune cells and cytokines.
银屑病是一种无法治愈的自身免疫性皮肤病，是最常见的免疫介导性疾病之一。目前，众多临床研究正在进行中，且有多种治疗方案可供选择。然而，这些治疗方法侧重于改善疾病症状，无法实现根治；它们还存在一定的毒副作用。近年来，天然产物因其高效低毒而越来越受到关注。尽管天然产物具有明显的治疗效果，但其生物活性受到稳定性差、溶解性差和生物利用度低的限制。新型药物递送系统，包括脂质体、脂质球、纳米结构脂质载体、非离子表面活性剂囊泡、纳米乳剂、纳米球、微针、醇质体、纳米晶体和泡沫，有可能克服传统药物递送系统中水溶性和渗透性差的局限性。因此，为达到治疗效果，药物能够到达银屑病皮损的表皮和真皮，与免疫细胞和细胞因子相互作用。
