School of Medicine, Gaziantep University, Gaziantep, Turkey.
Inflammation. 2012 Apr;35(2):405-8. doi: 10.1007/s10753-011-9328-2.
The aim of our study is to determine the serum visfatin levels of patients with Behcet's disease and to investigate the relationship between visfatin, an adipokine released from adipose tissue, levels and activity of Behcet's disease. Fifty-eight patients with Behcet's disease were enrolled to the study. Nineteen of the patients were inactive, and 39 of them were active. We enrolled 30 healthy subjects as being control group. Visfatin and tumor necrosis factor alpha (TNF-α) levels were measured with ELISA method. Visfatin levels were significantly lower in patients with Behcet's disease whose illnesses were active or inactive than the control group (p < 0.05). There was no significant difference between the active patient and inactive patient group. The reason for the lower levels of serum visfatin in active and inactive patients' group could be due to pro-inflammatory cytokines such as TNF-α and IL-6 which suppress genetic expression of visfatin in patients with Behcet's disease, or else.
我们研究的目的是确定 Behcet 病患者的血清内脂素水平，并探讨内脂素（一种脂肪组织释放的脂肪细胞因子）水平与 Behcet 病活动之间的关系。本研究纳入了 58 例 Behcet 病患者。其中 19 例为非活动期，39 例为活动期。我们纳入 30 名健康受试者作为对照组。采用 ELISA 法检测内脂素和肿瘤坏死因子-α（TNF-α）水平。与对照组相比，活动期和非活动期 Behcet 病患者的内脂素水平显著降低（p<0.05）。但在活动期和非活动期患者之间无显著差异。导致活动期和非活动期患者血清内脂素水平降低的原因可能是由于 TNF-α和 IL-6 等促炎细胞因子抑制了 Behcet 病患者内脂素的基因表达，或者其他原因。
