Department of Respiratory Medicine, Jiangyin People's Hospital, Nantong University, Jiangyin, People's Republic of China.
J Surg Oncol. 2011 Aug 1;104(2):181-6. doi: 10.1002/jso.21944. Epub 2011 Apr 14.
The purpose of this study was to evaluate the value of nm23-H1 and proliferating cell nuclear antigen (PCNA) expression as well as other confirmed prognostic factors in predicting the clinical outcome after definitive surgery of pathologic stage I non-small cell lung cancer (NSCLC).
Four hundred fifty-two consecutive and non-selected patients who underwent definitive surgery for stage I NSCLC were included in this study. Formalin-fixed paraffin-embedded specimens were stained for nm23-H1 and PCNA, the correlation between the staining and its clinicopathological parameters, and its prognostic power were analyzed statistically.
Of the 452 patients studied, 320 cases (70.8%) were high expression for nm23-H1. A total of 182 carcinomas (40.3%) were PCNA high expression tumors. PCNA expression correlated with serum CEA level (P < 0.001), and differentiation (P < 0.001). In univariate analysis by log-rank test, serum CEA level, pT stage, differentiation, nm23-H1 expression, and PCNA expression were significant prognostic factors (P = 0.037, 0.021, <0.001, 0.042, and 0.014, respectively). In multivariate analysis, pT stage and nm23-H1 expression maintained its independent prognostic influence on overall survival (P = 0.041 and 0.003, respectively).
nm23-H1 may be a good biomarker to be applied in clinic to predict the prognosis of patients with completely resected pathologic stage I NSCLC.
本研究旨在评估 nm23-H1 和增殖细胞核抗原（PCNA）表达以及其他已确认的预后因素在预测病理 I 期非小细胞肺癌（NSCLC）患者根治性手术后临床结局方面的价值。
本研究纳入了 452 例连续且未经选择的接受 I 期 NSCLC 根治性手术的患者。采用福尔马林固定石蜡包埋标本进行 nm23-H1 和 PCNA 染色，统计分析染色与临床病理参数的相关性及其预后能力。
在 452 例研究患者中，320 例（70.8%）nm23-H1 高表达。共有 182 例（40.3%）PCNA 高表达肿瘤。PCNA 表达与血清 CEA 水平（P < 0.001）和分化程度（P < 0.001）相关。对数秩检验的单因素分析显示，血清 CEA 水平、pT 分期、分化程度、nm23-H1 表达和 PCNA 表达是显著的预后因素（P = 0.037、0.021、<0.001、0.042 和 0.014）。多因素分析显示，pT 分期和 nm23-H1 表达对总生存仍具有独立的预后影响（P = 0.041 和 0.003）。
nm23-H1 可能是一种预测完全切除的病理 I 期 NSCLC 患者预后的良好生物标志物。
