China Military Institute of Chinese Meteria Medica, Intergrative Medicine Centre, 302 Military Hospital, Beijing 100039, China.
J Pharm Biomed Anal. 2011 Jul 15;55(5):1239-44. doi: 10.1016/j.jpba.2011.03.018. Epub 2011 Mar 17.
Musk is a precious and wide applied material in traditional Chinese medicine, also, an important material for the perfume industry all over the world. To establish a rapid, cost-effective and relatively objective assessment for the quality of musk, different musk samples, including authentic, fake and adulterate, were collected. A oxide sensor based electronic nose (E-nose) was employed to measure the musk samples, the E-nose generated data were analyzed by principal component analysis (PCA), the responses of 18 sensors of E-nose were evaluated by loading analysis. Results showed that a rapid evaluation of complex response of the samples could be obtained, in combination with PCA and the perception level of the E-nose was given better results in the recognition values of the musk aroma. The authentic, fake and adulterate musk could be distinguished by E-nose coupled with PCA, sensor 2, 3, 5, 12, 15 and 17 were found to be able to better discriminate between musk samples, confirming the potential application of an electronic instrument coupled with chemometrics for a rapid and on-line quality control for the traditional medicines.
麝香是一种在中药中应用广泛且珍贵的材料，也是世界各地香水行业的重要原料。为了对麝香的质量进行快速、经济高效且相对客观的评估，收集了不同的麝香样品，包括正品、赝品和掺假品。采用基于氧化物传感器的电子鼻（E-nose）对麝香样品进行测量，通过主成分分析（PCA）对 E-nose 生成的数据进行分析，通过加载分析评估 E-nose 的 18 个传感器的响应。结果表明，结合 PCA，可以快速评估样品的复杂响应，并且电子鼻的感知水平在麝香香气的识别值中给出了更好的结果。通过 E-nose 结合 PCA 可以区分正品、赝品和掺假麝香，发现传感器 2、3、5、12、15 和 17 能够更好地区分麝香样品，证实了电子仪器与化学计量学相结合用于快速在线控制传统药物质量的潜力。
